Henrikh Mkhitaryan got United off to a flying start with a a sweetly struck effort after 10 minutes, but Anderlecht hit back to level the tie through Sofiane Hanni.
The home side were on top for large periods of the match but were held at bay until the first half of extra time when Marcus Rashford fired past Ruben to send the Red Devils through.
Jose Mourinho’s team suffered more injury woes with Marcos Rojo stretchered off midway through the first half and Zlatan Ibrahimovic also picking up a nasty knee injury late on.
Scroll through the gallery above to find out how the Red Devils players performed in their Europa League clash with Anderlecht.
