Former Arsenal midfielder Craig Eastmond is back for Sutton after completing a three-game ban.
But Ben Jefford, Jack Jebb and Craig Dundas are all cup-tied and are not eligible for the non-league side.
Arsenal are without Laurent Koscielny who was forced off against Bayern Munich with a hamstring injury last week.
Theo Walcott leads the line for the Gunners with Alexis Sanchez named on the bench.
Arsenal Team: Ospina, Gabriel, Mustafi, Holding, Monreal, Elneny, Xhaka, Perez, Reine-Adelaide, Iwobi, Walcott
Subs: Martinez, Debuchy, Mertesacker, Gibbs, Maitland-Niles, Oxlade-Chamberlain, Sanchez
Sutton Team: Worner, Amankwaah, Downer, Collins, Beckwith, Deacon, Bailey, Eastmond, May, Gomis, Biamou
Subs:
Sutton United manager Paul Doswell said: “There’s two ways of looking at it [the game].
“You either get the likes of [Mesut] Ozil and [Alexis] Sanchez and [Olivier] Giroud – and you can just keep naming them – in which case we would lose the game comfortably but the lads would get the experience of having played a Premier League giant.
“If you see Ozil and Sanchez on the team sheet our chance doesn’t come beyond nought. Or you go the other way and you play a team of under-23s that are still internationals mixed in with one or two of their squad players, and that gives us that one percent chance that we’d be after.”
