In a match fitting enough to be the final, only one man can progress to try and don Roger Federer’s crown following the Swiss star’s shock quarter-final exit.
Nadal is in his first Wimbledon semi-final in seven years and he is hoping to end an eight-year drought at the All England Club.
Meanwhile, Djokovic can finally put his injury nightmares behind him by showing the world he is back to his best.
And Nadal knows he will be in for an extremely tough afternoon.
“It’s always is a big challenge face Novak,” Nadal said.
“It’s one of the more complex players that I ever saw on our sport. It’s always a big test.
“You know that you can’t win against him if you don’t play very well.
“But my goal is to try to play very well. I know in semi-finals of Wimbledon you will not have an easy opponent in front. You have to accept that if you want to win important things.
“Of course, you will face the best players. You need to be ready for it.”
Rafael Nadal vs Novak Djokovic LIVE
5.45pm: Isner is 8-7 up in the final set with Anderson on serve. Both players resolute with their deliveries but one slip-up and this match will be over.
5.30pm: Good afternoon and welcome to Wimbledon where we are awaiting the heavyweight battle between Rafael Nadal and Novak Djokovic.
John Isner and Kevin Anderson are about to wrap up their epic five-set match which has been ongoing for over four hours.
There will then be a half an hour break to put on the roof before Nadal and Djokovic take to the main stage here at the All England Club.
