
His response left Pamela in fits of giggles as the audience burst out laughing with them.
The Liverpudlian added: “I accept your compliment but that could well mean that you thought I was really ugly.”
The host then joked Pamela knows some information from her meetings with WikiLeaks founder Julian Assange, who quipped back: “I’m the least of anyone’s worries.”
John replied: “I don’t know, my wife’s not going to be too pleased!”
And viewers of the nightly programme soon flocked to social media to comment on their flirtatious behaviour.
“Pammy still got it!! You lucky Bishop… You stopped blushing yet? #gotthemoveslikebishop,” joked one person.
Another wrote: “@JohnBishop100 has just pulled Pammy Anderson on the nightly show!!”
“@ITVNightlyShow @JohnBishop100 She’s so into you John,” added a third.
The Nightly Show continues tonight at 10pm on ITV.
