The comedian is on course to land his professional dance partner Oti Mabuse, 30, her second consecutive win.
Not far off his heels is chart-topper HRVY, 21, who stands in good stead to secure Janette Manrara, 37, her first-ever win at 7/4.
EastEnders actress and Charles’ former co-star Maisie Smith, 19, seems to be holding the third position at 6/1.
Coral spokesperson John Hill said: “Bill is the one to beat this weekend. He has been the favourite to lift the Glitterball Trophy from early into this series.
“HRVY is sure to throw down a strong challenger to the favourite in what should be one of the best Strictly finals we have seen in recent years.”
Strictly Come Dancing continues Saturday at 6pm on BBC One.