Graham, 56, has welcomed a plethora of celebrity guests and A-list stars onto the infamous BBC red sofa over the past 20 years, interviewing them for his self-titled chat show, The Graham Norton show.
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The Irish-born presenter is also the UK commentator of the Eurovision Song Contest and has managed to work the two projects side by side since he took on the role from the late Terry Wogan in 2009.
However this year, there will be a slight disruption to proceedings as Graham will be replaced by a guest host on the BBC chat show when it airs later this month.
Comedian and The Brit Awards host Jack Whitehall, 30, will be stepping in for Graham as presenter of the show as the first guest host to ever take on the role.
Speaking of presenting the show, Jack said in a statement released by the BBC: “I was so honoured Graham asked me to do this for him.
“The thought of stepping into his huge showbiz boots fills me in equal measure with fear and excitement.
“Worst case, I will make everyone appreciate just how lucky we are to have him,” the comedian joked, with Graham stating he was leaving his show in capable hands.
The Irish man said: “I’m thrilled to know that I am leaving the show in Jack’s capable hands.
“He is bound to do an amazing job. I should warn him not to get too comfortable in my chair though, because like a slightly fey terminator, I’ll be back!!”
Jack will be welcoming Beauty and The Beast actor Luke Evans, 40, singer and former The Voice coach Paloma Faith, 37, as well as Game Of Thrones star Gwendoline Christie, 40.
The comedian’s presenting technique has seen him pick fun at some of the nation’s most loved stars and one remark at this year’s Brit Awards didn’t sit too well with Good Morning Britain presenter, Piers Morgan, 53.
Piers had been in a Twitter feud with members of pop group Little Mix about a risky photoshoot ahead of the awards ceremony earlier this year and when speaking to the girls about their beef with the presenter, Jack said: “Voluptuous breasts and four chins, must have been like looking in the mirror [for Piers].”
Appearing on Good Morning Britain after the ceremony, Jack said when faced by Piers: “I feel like I’ve been brought into the headmaster’s office.
“I wanted some beef at the Brits,” Jack joked, before continuing: “No it is totally unacceptable, I knew you would have a good sense of humour and would take it on your chins.
“You’re my favourite pantomime villain, I can’t help myself. Maybe I’m obsessed with you,” Jack remarked, before Piers labelled himself as a “national treasure.”
Continuing the joke, Jack added: “You are a regional trinket at best,” to which Piers replied: “I actually like the jokes about me, I think they’re funny.”
Whereas, last year, Graham turned his attention to more topical matter, voicing his views on Brexit while making an appearance on RTE’s The Late Late Show and admitted a deal on leaving the EU was going to unfold whether the public liked it or not.
The BBC presenter said: “I shut my eyes, I do some deep breathing. There is a b*****-mindedness about it. Some sort of Brexit is going to happen.
“Even though at this point everyone knows it’s a bad idea. But I do think it is something very British.
“Well, I said I was hungry enough to eat my foot. So I’m going to eat my foot. So from next year we’ll be having toes as an amuse-bouche,” the chat show host went on to add.
The Graham Norton show airs Friday at 10.35pm on BBC One.