Wonder pill could help adults learn new language or instrument just like a child

Children find it easy to pick up a new language or learn to play music but as we age this ability declines dramatically making it harder.

But controlling a single brain chemical may help expand the window for learning language and music well into adulthood.

The findings could lead to new drugs to turn off this chemical so learning becomes a breeze.

Limiting the supply or the function of the neuromodulator adenosine in a brain structure called the auditory thalamus preserved the ability of adult mice to learn from passive exposure to sound much as young children learn from the soundscape of their world.

Dr Stanislav Zakharenko at St Jude Children’s Research Hospital in Memphis, Tennessee, said: “By disrupting adenosine signalling in the auditory thalamus, we have extended the window for auditory learning for the longest period yet reported, well into adulthood and far beyond the usual critical period in mice

“These results offer a promising strategy to extend the same window in humans to acquire language or musical ability by restoring plasticity in critical regions of the brain, possibly by developing drugs that selectively block adenosine activity.”

The auditory thalamus is the brain’s relay station where sound is collected and sent to the auditory cortex for processing. 

The auditory thalamus and cortex rely on the neurotransmitter glutamate to communicate. 

Adenosine reduces glutamate levels by inhibiting this neurotransmitter’s release. 

The study also linked adenosine inhibition to reduced brain plasticity and the end of efficient auditory learning.

Researchers used a variety of methods to demonstrate that reducing adenosine or blocking the A1 adenosine receptor that is essential to the chemical messenger’s function changed how adult mice responded to sound.

Much as young children pick up language simply by hearing it spoken, they showed when adenosine was reduced or the A1 receptor blocked in the auditory thalamus, adult mice passively exposed to a tone responded to the same tone stronger when it was played weeks or months later. 

These adult mice also gained an ability to distinguish between very close tones or tones with similar frequencies. 

Mice usually lack this “perfect pitch” ability.

Researchers also showed the experimental mice retained the improved tone discrimination for weeks.

Dr Zakharenko added: “Taken together, the results demonstrated that the window for effective auditory learning re-opened in the mice and that they retained the information.”

The experimental compound FR194921 was used to selectively blocks the A1 receptor. 

If paired with sound exposure, the compound rejuvenated auditory learning in adult mice. 

Dr Zakharenko said: “That suggests it might be possible to extend the window in humans by targeting the A1 receptor for drug development.”

The study also linked the age-related decline in ease of auditory learning to an age-related increase in an enzyme (ecto-5′-nucleotidase) involved in adenosine production in the auditory thalamus. 

Mature mice had higher levels than newborn mice of the enzyme and adenosine in the auditory thalamus. 

Deletion of this enzyme returned the adenosine level in adult mice to the level of newborn mice. 

Further research will look for compounds that target ecto-5′-nucleotidase as an alternative approach for extending the window of auditory learning.

The study was published in the journal Science.