NHS Providers, which represents hospital, mental health and ambulance trusts, warned services simply do not have enough money to keep running safely.
The group also predicted longer waits for hospital operations and more delays in A&E as a result.
Despite Chancellor Philip Hammond’s pledge to pump extra money into the NHS, the health trust predicts its members, which account for nearly two-thirds of health spending, will get £89.1billion in 2017-18.
This amounts to 2.6 per cent more than they received this year, but crucially just half of the 5.2 per cent expected growth in demand.
Jonathan Ashworth MP, Labour’s shadow health secretary, said: “This unprecedented warning from trusts is a new low for this Government’s disgraceful handling of our NHS.
“Theresa May has downplayed the worst winter crisis on record, in which nine out of ten hospitals were dangerously overcrowded, and ducked her responsibility to patients by failing to provide significant funding in the Spring Budget.
“Years of damaging Tory neglect have left the NHS unable to deliver on its constitution and yet ministers remain in denial of the crisis they have created.
“The public now expects urgent and immediate action to provide patients with the world-class, 21st Century health and social care system they truly deserve.”
Chris Hopson, NHS Providers’ chief executive, earlier today told the BBC it was time for the Government to “sit up and listen” and added the NHS faces “mission impossible” to meet the standards required by the Government.
He said: “NHS trusts will strain every sinew to deliver the commitments made for the health service. But we now have a body of evidence showing that, with resources available, the NHS can no longer deliver what the NHS constitution requires of it.
“We fear that patient safety is increasingly at risk.”
The analysis carried out by NHS Providers predicts the numbers waiting in A&E longer than the four-hour target will increase by 40 per cent next year to 1.8m.
Numbers waiting beyond the 18-week target for routine treatments, such as knee and hip operations, will go up by a shocking 150 per cent to around 100,000, the group calculates.
A Department of Health spokeswoman said extra money was being invested in the NHS and pointed out the Budget had set aside more funding for social care, which would also help relieve the pressures on hospitals in particular.
She added the Government had a “strong plan to improve performance” and accused NHS Providers of failing to acknowledge the steps that were being taken.