However, there was one scene from last week’s episode The Inspiration Deprivation in which she had to do some uncomfortable filming scenes.
In the show, Amy is persuaded to use a sensory deprivation tank by partner Sheldon Cooper (played by Jim Parsons) to calm her nerves before competing for the Nobel prize.
The actress has revealed the scenes were not ones she would miss and it triggered massive anxiety.
She posted on her Grok Nation blog: “In real life I’m claustrophobic. I was not at all excited to be placed in this giant Mork & Mindy type egg thing with the cover closed. The cover was controlled by a person holding a string that rigged the cover open, so there was the issue of human error adding to my worry.
“When filming, we would wait until the very last second before cameras were rolling to shut me into my pod. The only blessed relief was that I was able to see some light coming in through the back of the pod where the lid met the unit, so that actually helped. It relieved me of the feeling of being held underwater.”
She also implored fans to relate to her situation and the sacrifices she made to make the final season scenes.
She added: ”If you’ve never experienced claustrophobia, that’s what it can feel like: your throat closing in, water from some unknown source filling your chest and neck and head up as death greets you with her steely gaze inside of your mind.
“Needless to say, this wasn’t one of my favourite scenes to film.”
The tank acts as relief for Amy, but for the actress it was a scene she had to tolerate than enjoy doing.
The episode saw the hit show return to fans after a month break.
Meanwhile, the star has been struggling to come to terms with the show’s ending and has used her blog as a means to express her emotions.
In a recent post she reported her dressing room was being dismantled on the set and she explained what it had meant to her.
She wrote: “The details of the end of something are always complicated. Things don’t just end. They cease to be, and we have to literally dismantle the structures that held them up.
“My dressing room held me up in so many ways. And all of this is so bittersweet. But honestly, the taking down of the things that comforted me feels mostly bitter!”