Dec was presenting the show alone for the second week in a row after Ant stepped down from his TV commitments following his drink-drive charge last month.
He appeared thrilled to be hosting the final instalment from the Sunshine State as he began the show with a musical number.
However as he greeted the audience he made a small slip-up.
“Hello and welcome to your Saturday Night Takeaway live from Universal Orlando Resort in Florida,” Dec exclaimed.
He went on to note: “Where it has literally just started to rain.”
As he continued with his opening he monologue, he made a small mistake as he revealed the show had made history by having more people than ever on the plane to Florida for the live show.
“We have more Place on the Plane with us…,” he noted before quickly correcting himself: “Place on the Plane winners with us than ever before.”
Despite the minor hiccup, Dec managed to sail through the rest of his monologue without another slip-up.
However, tonight’s guest announcer Denise Richards suffered an awkward blunder too.
Commenting on who she thought could be the next James Bond, she confused “Geordie” with “Georgie”.
The gaffe happened when Dec asked who could replace Daniel Craig.
Denise said she believed guest Craig David could be in with a chance of playing 007.
But she stumbled when she offered up another suggestion.
“Well, if you want to go in a different direction, you could cast the first Georgie Bond, Scarlett Moffatt,” the actress laughed.
Giggling at her error, Dec corrected: “Ah Geordie Bond I think you mean, Geordie Bond.”
Following tonight’s show, Dec revealed that he missed his co-host Ant.
In a video obtained by The Sun, which was taken after the episode came to a close, he referenced the 42-year-old’s absence.
When a member of the audience called out: “We miss Ant,” he replied: “Yes, we do, we do. It’s tinged with sadness.”
He went on to ask: “Can you all give a one round of applause for Ant who is at home?”
Saturday Night Takeaway is available to watch on ITV Hub now.