The Spaniard overcame Fabio Fognini in the last 16 yesterday as he brushed the Italian aside 6-3 6-1.
Nadal goes into the match full of confidence with a 14-match winning streak behind him that includes a win over Dimitrov.
The Bulgarian came up against Nadal in the China Open semi-finals just six days ago and lost in straight sets.
Victory for Nadal today would take him to 870 career wins – tying Andre Agassi for sixth place on the Open Era career wins list.
Play is due to start at around 8am and you can follow live updates of the match below.
Rafael Nadal vs Grigor Dimitrov: LIVE Shanghai Masters updates
(*Denotes next server)
*Nadal 2-3 Dimitrov
Lightning quick reactions from Nadal as he makes Dimitrov stretch for a wide shot and then fires back into open space.
You feel Nadal is just starting to find his rhythm with some forehand shots but Dimitrov holds his serve.
Nadal 2-2 *Dimitrov
Nadal again loses the first point before serving up an ace to level at 15-15.
Nadal then shows his versatility winning a point from the back of the court with a long rally and then his reactions at the net prove too quick for his opponent to edge 40-15 in front.and then wraps up the game with a ferocious forehand.
*Nadal 1-2 Dimitrov
“Amazing – point of the week!” shouts the commenntator as Dimtrov sends Nadal long down the line as the ball clips the top of the net, only for the Spaniard to somehow reach it.
But Nadal’s shot lands just over the net and Dimitrov toys with his opponent as his return drop shot is out of reach for Nadal.
Nadal 1-1 *Dimitrov
Some early nerves for Nadal as he faults on his first serve and then puts a forehand long to fall 15-0 behind.
Dimitrov surely didn’t expect to find himelf on break point so early in the match but hits the net at the crucial moment.
Nadal overcomes his slight wobble when his opponent hits the net again and it’s all square.
But it’s plain sailing
*Nadal 0-1 Dimitrov
Dimitrov races two a 30-0 lead before Nadal gets his first point on the board.
The Bulgarian then sees out the game with a powerful serve to settle his nerves.
07:45: Both players will be due on court any minute now following Marin Cilic’s 6-3 6-4 win over Albert Ramos.