Mourinho is coming under increasing pressure at Old Trafford after United made their worse start to a league campaign since the 1989/90 season.
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A run of four winless games, the most recent of which came against Valencia on Tuesday night, has seen United chiefs face calls to sack the Portuguese.
And Jose Mourinho will be mindful that his job is on the line as United prepare to welcome Newcastle to town on Saturday.
Ex-Red Devil Paul Ince believes Mourinho will be in “real danger” if his old side fail to get a result against the Magpies.
Ince’s former England team-mate Keown agrees with his take on Mourinho’s future being in jeopardy.
And he says defeat to Newcastle coupled with fans getting on his back will spell the end of his reign in Manchester.
“I don’t believe he can — especially if he loses the fans,” Keown told the Daily Mail, when asked if Mourinho can survive defeat to Newcastle.
“The Manchester United faithful have been incredibly patient with their team. So far, Mourinho has not lost them.
“The players are playing with fear. Is it any wonder their confidence is looking brittle if their manager is ranting for 45 minutes before an important match?
“That could go some way to explaining why United looked devoid of confidence against Valencia.
“As a former player, I would love to pull on my boots and play for Jurgen Klopp or Pep Guardiola.
“With these managers, you feel they are taking every step with their players. They nurture their players and only have their best interests at heart.
“With Mourinho, it feels like the players are on their own. It is like they are always on trial. It must be a lonely road for them at United.”
Zinedine Zidane and Mauricio Pochettino have already been touted as potential candidates to replace Mourinho.
But United legend Ryan Giggs has urged the top brass at Old Trafford to stick with the former Chelsea gaffer.
“No [he should not be sacked],” Giggs said. “They are going through a tough time but change and you will be in the same position in a year or two years.
“I believe [Mourinho] should keep his job. The problem of late has been forward planning. So just take stock, it’s a tough time, but my stance hasn’t changed.”
Graeme Souness, meanwhile, has backed Giggs to replace Mourinho if Ed Woodward does wield the axe.
“I wouldn’t go with Zidane,” Souness said. “I don’t think they want another big one given a short space of time to get it right.
“If I was having a say, I would be looking at, sounds daft, Ryan Giggs. Someone that will be given more time going forward to get it right.
“It doesn’t have to be a spending splurge again. It has to be someone this time around that will be given time because of his affection and his history with the football club.
“They’ve tried [Louis] Van Gaal, they’ve tried [David] Moyes, who knew his way in the Premier League. They’ve gone for arguably the biggest name in Mourinho and it’s been an unmitigated disaster just spending big money chasing it. And that’s when you make mistakes.”