The 58-year-old Scot spoke to two DJs of Brixton’s Reprezent Radio, which the royal couple paid a visit to yesterday.
The host wondered: “You guys meet a lot of famous people coming into the studio, all big music names.
“How do they compare to the likes of the Gallagher brothers and people like that? How do they compare to them?”
The girls started to explain that they were just a regular couple, but it seemed that viewers were distracted by Lorraine’s initial question.
One posted on Twitter with some laughing emojis: “Lorraine actually asking how Harry and Meghan compare to the Gallagher brothers.”
Another asked: “Lorraine comparing the evil Gallagher brothers with royalty. Hmmmm.”
A third simply raged: “Arrrggghhhhh more pointless discussions.”
Lorraine airs weekdays on ITV from 8.30am.