The UFC lightweight champion has called 50 Cent a female by posting a photo of the rapper topless on International Women’s Day.
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McGregor was mocking the size of the singer-songwriter’s breasts and comparing them to that of the opposite sex.
The post comes after a tense few days where the pair have been at each other’s throats with a string of nasty Instagram posts.
In his latest effort, McGregor claims to run New York – 50 Cent’s home town – in a blatant attempt to get another one over the artist.
“International Women’s day everyone!,” McGregor wrote.
“Get your **** out for the lads ladies. We love you.
“Superior genes my big ******** mate.
“I am made of granite. You need a bra. You jabbed up fool.
“Hahahaha you should have stayed quiet and promoted that fight for me on the free like you did. But you just kept going with them ******* memes.
“Your 50, 50. 50 years old. **** off.
“It’s all love tho fifty serious, you are a mad bastard, but we still proper love a few of your tunes over on this side of the world.
“I even blasted one of them on the free walking into madison square garden to take one of my belts.
“It was called I run New York. @beatsbydre”
The two public figures have been at war ever since Floyd Mayweather knocked McGregor out in their multi-million pound boxing match last year.
The Irishman is next expected to return to the Octagon, but the details of his fight are still unclear.