The 31-year-old has been absent from the sport for almost two years since losing in gruesome fashion to Canelo Alvarez in 2016, jumping up two divisions to challenge for the middleweight world title.
Despite boxing well for the first half of the fight, he was knocked out in brutal fashion in the sixth round as the Mexican’s physical superiority proved too much to handle.
“The reason I took the Canelo fight is that I got quite desperate,” he explained to Sky Sports this week.
“I really wanted a big super fight and I wanted my name up on the Vegas strip. It’s always been my dream.
“The mistake I made in there was my own fault. I dropped my left hand and I got caught over the top with Canelo’s right hand.
“I would rather be knocked out with one big shot instead of taking numerous punches and getting stopped that way, so I’m glad it was just that one shot.”
On Saturday night, the Bolton man will begin his quest to reclaim a world title when he takes on Canadian Lo Greco at the Echo Arena in Liverpool.
And the former unified light-welterweight champion will have to do it without the help of long-time trainer Virgil Hunter, who has stepped away from the sport with undisclosed health problems.
Joe Goossen is the man who been has selected to replace veteran cornerman Hunter and Khan admitted he is feeling the nerves ahead of his return to the limelight.
“I am a little bit nervous but I know my fitness is right, I’ve trained hard for this,” he said.
“I do feel a lot better than I did at 28. I’m 31 now, I’m at the peak of my career, I know I have a bit left in me to come back.
“I want to win another world title, that’s what keeps me going.”
Speaking about his relationship with Goossen, Khan claimed the 64-year-old, who has trained the likes of Shane Mosley and Rafael Ruelas, has kept him sharp.
“He’s a trainer that’s always watching you. When I’m training he’ll always be watching me, I’ve seen videos of him just watching me,” he continued.
“He doesn’t take his eyes off me, seeing what mistakes I’m making, telling me whilst I’m training, ‘Amir your left hand’s dropping, your right hand’s dropping, keep your hands up higher’.
“It’s nice to have someone like him there, he’s experienced he’s trained some great champions in his day, and I still believe he’s a great trainer, I’m glad to have him here.”